TY - JOUR
T1 - Serial echocardiographic and Doppler evaluation of left ventricular diastolic filling in full-term neonates
AU - Areias, Jose C.
AU - Meyer, Robin
AU - Scott, William A.
AU - Goldberg, Stanley J.
N1 - Funding Information:
From the Departments of Pediatrics and Physiology, University of Porto, Porto, Portugal, and the Department of Pediatrics and Children’s Research Center, University of Arizona, Health Sciences Center, 1501 North Campbell Avenue, Tucson, Arizona 85724. This study was supported by the Pediatric Cardiology Research Fund, University of Arizona, Health Sciences Center, Tucson, Arizona and the Junta National de Investigacas Cientifica e Technologica, University of Porto, Porto, Portugal. Manuscript received December 11, 1989; revised manuscript received and accepted February 20,199O.
PY - 1990/7/1
Y1 - 1990/7/1
N2 - Quantitative structural differences exist between fetal and adult myocardium.1 In the fetus, noncontractile tissue constitutes about 70% of muscle mass in contrast to findings in the adult myocardium in which noncontractile elements represent only about 40% of muscle mass.1 Friedman2 studied isolated myocardium and showed that there was less active tension and higher passive stiffness in fetuses than in adult lambs, suggesting that fetal myocardium is less compliant than adult myocardium. Previous echocardiographic and Doppler studies in fetuses and neonates detected a pattern of mitral velocities showing a lower E-wave amplitude when compared with later normal mitral E peaks.3,4 These studies detected less early left ventricular (LV) filling in fetuses and neonates that could be related to diminished relaxation and higher muscular stiffness. Previous investigators5 followed diastolic LV function in neonates up to the first 4 days of life and, therefore, did not determine the pattern of functional diastolic maturation. Further, prior studies of the neonate have not assessed LV isovolumic relaxation time by serial noninvasive measurement. Our study evaluates, by serial echocardiography and Doppler observations, the LV diastolic filling pattern in full-term neonates after birth and during the first 3 weeks of life to observe the natural evolution in LV diastolic function.
AB - Quantitative structural differences exist between fetal and adult myocardium.1 In the fetus, noncontractile tissue constitutes about 70% of muscle mass in contrast to findings in the adult myocardium in which noncontractile elements represent only about 40% of muscle mass.1 Friedman2 studied isolated myocardium and showed that there was less active tension and higher passive stiffness in fetuses than in adult lambs, suggesting that fetal myocardium is less compliant than adult myocardium. Previous echocardiographic and Doppler studies in fetuses and neonates detected a pattern of mitral velocities showing a lower E-wave amplitude when compared with later normal mitral E peaks.3,4 These studies detected less early left ventricular (LV) filling in fetuses and neonates that could be related to diminished relaxation and higher muscular stiffness. Previous investigators5 followed diastolic LV function in neonates up to the first 4 days of life and, therefore, did not determine the pattern of functional diastolic maturation. Further, prior studies of the neonate have not assessed LV isovolumic relaxation time by serial noninvasive measurement. Our study evaluates, by serial echocardiography and Doppler observations, the LV diastolic filling pattern in full-term neonates after birth and during the first 3 weeks of life to observe the natural evolution in LV diastolic function.
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U2 - 10.1016/0002-9149(90)90747-O
DO - 10.1016/0002-9149(90)90747-O
M3 - Article
C2 - 2360526
AN - SCOPUS:0025338437
SN - 0002-9149
VL - 66
SP - 108
EP - 111
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 1
ER -