Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis

B. Y. Reed, J. E. Zerwekh, K. Sakhaee, N. A. Breslau, F. Gottschalk, C. Y C Pak

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

We have previously reported that bone formation is impaired on histomorphometric analysis of bone in patients with idiopathic osteoporosis. In the present study, 30 patients with idiopathic osteoporosis (18 men and 12 women mean age 44 ± 12 years) and spinal and/or appendicular fractures were studied. Compared with control values, bone biopsy analysis demonstrated reduced bone volume (13.0 ± 4.4 vs. 23.2 ± 4.4, p < 0.0001), osteoid volume (0.13 ± 0.13 vs. 0.32 ± 0.19, p = 0.001), osteoid surface (5.9 ± 4.3 vs. 12.1 ± 4.6, p = 0.0004), and diminished double-labeled mineralizing surface (MS/BS 2.0 ± 2.1 vs. 5.1 ± 2.7%, p = 0.0001) in the patients. Since insulin-like growth factor 1 (IGF-1) is one of the major determinants of bone growth and remodeling, we measured the circulating level of this growth factor in these patients. The mean serum IGF-1 concentration was lower in patients as compared with 33 healthy age-matched controls (193 ± 59 SD ng/ml vs. 232 ± 79). A significant difference was noted between the two groups only in subjects younger than 36 years. In patients with idiopathic osteoporosis, regression analysis of serum IGF-1 against the various histological parameters measured from the bone biopsy disclosed significant correlation's between serum IGF-1 and osteoblastic surface (r = 0.429, p = 0.032), mineralizing bone surface with a double label (r = 0,480, p = 0.015), and the bone formation rate (r = 0.457, p = 0.021). These findings suggest that in young eugonadal individuals with idiopathic osteoporosis, reduced IGF-I concentrations may have an etiological role in the development of this disease.

Original languageEnglish (US)
Pages (from-to)1218-1224
Number of pages7
JournalJournal of Bone and Mineral Research
Volume10
Issue number8
StatePublished - 1995

Fingerprint

Insulin-Like Growth Factor I
Osteoporosis
Somatomedins
Bone and Bones
Serum
Osteogenesis
Biopsy
Bone Remodeling
Bone Development
Intercellular Signaling Peptides and Proteins
Regression Analysis

ASJC Scopus subject areas

  • Surgery

Cite this

Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis. / Reed, B. Y.; Zerwekh, J. E.; Sakhaee, K.; Breslau, N. A.; Gottschalk, F.; Pak, C. Y C.

In: Journal of Bone and Mineral Research, Vol. 10, No. 8, 1995, p. 1218-1224.

Research output: Contribution to journalArticle

Reed, B. Y. ; Zerwekh, J. E. ; Sakhaee, K. ; Breslau, N. A. ; Gottschalk, F. ; Pak, C. Y C. / Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis. In: Journal of Bone and Mineral Research. 1995 ; Vol. 10, No. 8. pp. 1218-1224.
@article{1fb8e979750f4c02affece26800e8ed1,
title = "Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis",
abstract = "We have previously reported that bone formation is impaired on histomorphometric analysis of bone in patients with idiopathic osteoporosis. In the present study, 30 patients with idiopathic osteoporosis (18 men and 12 women mean age 44 ± 12 years) and spinal and/or appendicular fractures were studied. Compared with control values, bone biopsy analysis demonstrated reduced bone volume (13.0 ± 4.4 vs. 23.2 ± 4.4, p < 0.0001), osteoid volume (0.13 ± 0.13 vs. 0.32 ± 0.19, p = 0.001), osteoid surface (5.9 ± 4.3 vs. 12.1 ± 4.6, p = 0.0004), and diminished double-labeled mineralizing surface (MS/BS 2.0 ± 2.1 vs. 5.1 ± 2.7{\%}, p = 0.0001) in the patients. Since insulin-like growth factor 1 (IGF-1) is one of the major determinants of bone growth and remodeling, we measured the circulating level of this growth factor in these patients. The mean serum IGF-1 concentration was lower in patients as compared with 33 healthy age-matched controls (193 ± 59 SD ng/ml vs. 232 ± 79). A significant difference was noted between the two groups only in subjects younger than 36 years. In patients with idiopathic osteoporosis, regression analysis of serum IGF-1 against the various histological parameters measured from the bone biopsy disclosed significant correlation's between serum IGF-1 and osteoblastic surface (r = 0.429, p = 0.032), mineralizing bone surface with a double label (r = 0,480, p = 0.015), and the bone formation rate (r = 0.457, p = 0.021). These findings suggest that in young eugonadal individuals with idiopathic osteoporosis, reduced IGF-I concentrations may have an etiological role in the development of this disease.",
author = "Reed, {B. Y.} and Zerwekh, {J. E.} and K. Sakhaee and Breslau, {N. A.} and F. Gottschalk and Pak, {C. Y C}",
year = "1995",
language = "English (US)",
volume = "10",
pages = "1218--1224",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis

AU - Reed, B. Y.

AU - Zerwekh, J. E.

AU - Sakhaee, K.

AU - Breslau, N. A.

AU - Gottschalk, F.

AU - Pak, C. Y C

PY - 1995

Y1 - 1995

N2 - We have previously reported that bone formation is impaired on histomorphometric analysis of bone in patients with idiopathic osteoporosis. In the present study, 30 patients with idiopathic osteoporosis (18 men and 12 women mean age 44 ± 12 years) and spinal and/or appendicular fractures were studied. Compared with control values, bone biopsy analysis demonstrated reduced bone volume (13.0 ± 4.4 vs. 23.2 ± 4.4, p < 0.0001), osteoid volume (0.13 ± 0.13 vs. 0.32 ± 0.19, p = 0.001), osteoid surface (5.9 ± 4.3 vs. 12.1 ± 4.6, p = 0.0004), and diminished double-labeled mineralizing surface (MS/BS 2.0 ± 2.1 vs. 5.1 ± 2.7%, p = 0.0001) in the patients. Since insulin-like growth factor 1 (IGF-1) is one of the major determinants of bone growth and remodeling, we measured the circulating level of this growth factor in these patients. The mean serum IGF-1 concentration was lower in patients as compared with 33 healthy age-matched controls (193 ± 59 SD ng/ml vs. 232 ± 79). A significant difference was noted between the two groups only in subjects younger than 36 years. In patients with idiopathic osteoporosis, regression analysis of serum IGF-1 against the various histological parameters measured from the bone biopsy disclosed significant correlation's between serum IGF-1 and osteoblastic surface (r = 0.429, p = 0.032), mineralizing bone surface with a double label (r = 0,480, p = 0.015), and the bone formation rate (r = 0.457, p = 0.021). These findings suggest that in young eugonadal individuals with idiopathic osteoporosis, reduced IGF-I concentrations may have an etiological role in the development of this disease.

AB - We have previously reported that bone formation is impaired on histomorphometric analysis of bone in patients with idiopathic osteoporosis. In the present study, 30 patients with idiopathic osteoporosis (18 men and 12 women mean age 44 ± 12 years) and spinal and/or appendicular fractures were studied. Compared with control values, bone biopsy analysis demonstrated reduced bone volume (13.0 ± 4.4 vs. 23.2 ± 4.4, p < 0.0001), osteoid volume (0.13 ± 0.13 vs. 0.32 ± 0.19, p = 0.001), osteoid surface (5.9 ± 4.3 vs. 12.1 ± 4.6, p = 0.0004), and diminished double-labeled mineralizing surface (MS/BS 2.0 ± 2.1 vs. 5.1 ± 2.7%, p = 0.0001) in the patients. Since insulin-like growth factor 1 (IGF-1) is one of the major determinants of bone growth and remodeling, we measured the circulating level of this growth factor in these patients. The mean serum IGF-1 concentration was lower in patients as compared with 33 healthy age-matched controls (193 ± 59 SD ng/ml vs. 232 ± 79). A significant difference was noted between the two groups only in subjects younger than 36 years. In patients with idiopathic osteoporosis, regression analysis of serum IGF-1 against the various histological parameters measured from the bone biopsy disclosed significant correlation's between serum IGF-1 and osteoblastic surface (r = 0.429, p = 0.032), mineralizing bone surface with a double label (r = 0,480, p = 0.015), and the bone formation rate (r = 0.457, p = 0.021). These findings suggest that in young eugonadal individuals with idiopathic osteoporosis, reduced IGF-I concentrations may have an etiological role in the development of this disease.

UR - http://www.scopus.com/inward/record.url?scp=0029100132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029100132&partnerID=8YFLogxK

M3 - Article

C2 - 8585426

AN - SCOPUS:0029100132

VL - 10

SP - 1218

EP - 1224

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 8

ER -