Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient

Bibhuti B. Das, Lawrence Shoemaker, Edward Kim, Christopher E. Mascio, Erle H. Austin

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.

Original languageEnglish (US)
Pages (from-to)E162-E166
JournalPediatric Transplantation
Volume16
Issue number5
DOIs
StatePublished - Aug 1 2012

Keywords

  • pediatric cardiac transplantation
  • sarcoidosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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