Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient

Bibhuti B. Das, Lawrence Shoemaker, Edward Kim, Christopher E. Mascio, Erle H. Austin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.

Original languageEnglish (US)
JournalPediatric Transplantation
Volume16
Issue number5
DOIs
StatePublished - Aug 2012

Fingerprint

Dental Porcelain
Sarcoidosis
Aorta
Pediatrics
Hypoplastic Left Heart Syndrome
Coronary Stenosis
Hypercalcemia
Heart Transplantation
Mitral Valve
Heart Ventricles
Allografts
Transplants
Kidney
Transplant Recipients

Keywords

  • pediatric cardiac transplantation
  • sarcoidosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient. / Das, Bibhuti B.; Shoemaker, Lawrence; Kim, Edward; Mascio, Christopher E.; Austin, Erle H.

In: Pediatric Transplantation, Vol. 16, No. 5, 08.2012.

Research output: Contribution to journalArticle

Das, Bibhuti B. ; Shoemaker, Lawrence ; Kim, Edward ; Mascio, Christopher E. ; Austin, Erle H. / Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient. In: Pediatric Transplantation. 2012 ; Vol. 16, No. 5.
@article{ccba0ced849d443ebbb4319719365aed,
title = "Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient",
abstract = "We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.",
keywords = "pediatric cardiac transplantation, sarcoidosis",
author = "Das, {Bibhuti B.} and Lawrence Shoemaker and Edward Kim and Mascio, {Christopher E.} and Austin, {Erle H.}",
year = "2012",
month = "8",
doi = "10.1111/j.1399-3046.2011.01557.x",
language = "English (US)",
volume = "16",
journal = "Pediatric Transplantation",
issn = "1397-3142",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient

AU - Das, Bibhuti B.

AU - Shoemaker, Lawrence

AU - Kim, Edward

AU - Mascio, Christopher E.

AU - Austin, Erle H.

PY - 2012/8

Y1 - 2012/8

N2 - We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.

AB - We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.

KW - pediatric cardiac transplantation

KW - sarcoidosis

UR - http://www.scopus.com/inward/record.url?scp=84863728823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863728823&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3046.2011.01557.x

DO - 10.1111/j.1399-3046.2011.01557.x

M3 - Article

C2 - 21883745

AN - SCOPUS:84863728823

VL - 16

JO - Pediatric Transplantation

JF - Pediatric Transplantation

SN - 1397-3142

IS - 5

ER -