Severe glomerular sclerosis is not associated with poor outcome after kidney transplantation

Amy D. Lu, Dev Desai, Bryan D. Myers, Donald C. Dafoe, Edward J. Alfrey

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

BACKGROUND: The increased utilization of expanded criteria kidney donors has necessitated the reevaluation of multiple donor risk factors to insure the best outcome from this valuable resource. Reports of decreased graft survival in recipients of kidneys from donors with ≥20% glomerular sclerosis (GS) have led many transplant centers to refuse these donor kidneys. The purpose of this study is to compare outcome in recipients of cadaveric donor kidneys with ≥20% GS versus those with <20% or no GS at our center. METHODS: We retrospectively reviewed 18 donor and 19 recipient and outcome variables in 89 recipients of kidneys, which were biopsied at the time of transplantation, between February 1995 and November 1998. We evaluated outcome based upon the percent of GS and the degree of vasculopathy. RESULTS: Donors with ≥20% GS were older and had more hypertension. Recipients of kidneys with ≥20% GS were older, had higher serum creatinine values at 1 and 2 years, but similar rates of delayed graft function and 2-year graft survival. Vasculopathy did not correlate to any important donor criteria except the percent GS. However, serum creatinine was significantly higher in recipients of kidneys with moderate vasculopathy versus none, up to 2 years after transplantation. There was no significant difference in graft loss based upon vasculopathy. CONCLUSIONS: Kidneys from donors with ≥20% GS provide excellent outcome similar to kidneys from donors with no GS.

Original languageEnglish (US)
Pages (from-to)470-474
Number of pages5
JournalAmerican Journal of Surgery
Volume180
Issue number6
DOIs
StatePublished - 2000

Fingerprint

Sclerosis
Kidney Transplantation
Kidney
Graft Survival
Creatinine
Transplantation
Delayed Graft Function
Transplants
Serum
Hypertension

ASJC Scopus subject areas

  • Surgery

Cite this

Severe glomerular sclerosis is not associated with poor outcome after kidney transplantation. / Lu, Amy D.; Desai, Dev; Myers, Bryan D.; Dafoe, Donald C.; Alfrey, Edward J.

In: American Journal of Surgery, Vol. 180, No. 6, 2000, p. 470-474.

Research output: Contribution to journalArticle

Lu, Amy D. ; Desai, Dev ; Myers, Bryan D. ; Dafoe, Donald C. ; Alfrey, Edward J. / Severe glomerular sclerosis is not associated with poor outcome after kidney transplantation. In: American Journal of Surgery. 2000 ; Vol. 180, No. 6. pp. 470-474.
@article{08f5582b0a8948e189b14168b49e43ab,
title = "Severe glomerular sclerosis is not associated with poor outcome after kidney transplantation",
abstract = "BACKGROUND: The increased utilization of expanded criteria kidney donors has necessitated the reevaluation of multiple donor risk factors to insure the best outcome from this valuable resource. Reports of decreased graft survival in recipients of kidneys from donors with ≥20{\%} glomerular sclerosis (GS) have led many transplant centers to refuse these donor kidneys. The purpose of this study is to compare outcome in recipients of cadaveric donor kidneys with ≥20{\%} GS versus those with <20{\%} or no GS at our center. METHODS: We retrospectively reviewed 18 donor and 19 recipient and outcome variables in 89 recipients of kidneys, which were biopsied at the time of transplantation, between February 1995 and November 1998. We evaluated outcome based upon the percent of GS and the degree of vasculopathy. RESULTS: Donors with ≥20{\%} GS were older and had more hypertension. Recipients of kidneys with ≥20{\%} GS were older, had higher serum creatinine values at 1 and 2 years, but similar rates of delayed graft function and 2-year graft survival. Vasculopathy did not correlate to any important donor criteria except the percent GS. However, serum creatinine was significantly higher in recipients of kidneys with moderate vasculopathy versus none, up to 2 years after transplantation. There was no significant difference in graft loss based upon vasculopathy. CONCLUSIONS: Kidneys from donors with ≥20{\%} GS provide excellent outcome similar to kidneys from donors with no GS.",
author = "Lu, {Amy D.} and Dev Desai and Myers, {Bryan D.} and Dafoe, {Donald C.} and Alfrey, {Edward J.}",
year = "2000",
doi = "10.1016/S0002-9610(00)00502-X",
language = "English (US)",
volume = "180",
pages = "470--474",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Severe glomerular sclerosis is not associated with poor outcome after kidney transplantation

AU - Lu, Amy D.

AU - Desai, Dev

AU - Myers, Bryan D.

AU - Dafoe, Donald C.

AU - Alfrey, Edward J.

PY - 2000

Y1 - 2000

N2 - BACKGROUND: The increased utilization of expanded criteria kidney donors has necessitated the reevaluation of multiple donor risk factors to insure the best outcome from this valuable resource. Reports of decreased graft survival in recipients of kidneys from donors with ≥20% glomerular sclerosis (GS) have led many transplant centers to refuse these donor kidneys. The purpose of this study is to compare outcome in recipients of cadaveric donor kidneys with ≥20% GS versus those with <20% or no GS at our center. METHODS: We retrospectively reviewed 18 donor and 19 recipient and outcome variables in 89 recipients of kidneys, which were biopsied at the time of transplantation, between February 1995 and November 1998. We evaluated outcome based upon the percent of GS and the degree of vasculopathy. RESULTS: Donors with ≥20% GS were older and had more hypertension. Recipients of kidneys with ≥20% GS were older, had higher serum creatinine values at 1 and 2 years, but similar rates of delayed graft function and 2-year graft survival. Vasculopathy did not correlate to any important donor criteria except the percent GS. However, serum creatinine was significantly higher in recipients of kidneys with moderate vasculopathy versus none, up to 2 years after transplantation. There was no significant difference in graft loss based upon vasculopathy. CONCLUSIONS: Kidneys from donors with ≥20% GS provide excellent outcome similar to kidneys from donors with no GS.

AB - BACKGROUND: The increased utilization of expanded criteria kidney donors has necessitated the reevaluation of multiple donor risk factors to insure the best outcome from this valuable resource. Reports of decreased graft survival in recipients of kidneys from donors with ≥20% glomerular sclerosis (GS) have led many transplant centers to refuse these donor kidneys. The purpose of this study is to compare outcome in recipients of cadaveric donor kidneys with ≥20% GS versus those with <20% or no GS at our center. METHODS: We retrospectively reviewed 18 donor and 19 recipient and outcome variables in 89 recipients of kidneys, which were biopsied at the time of transplantation, between February 1995 and November 1998. We evaluated outcome based upon the percent of GS and the degree of vasculopathy. RESULTS: Donors with ≥20% GS were older and had more hypertension. Recipients of kidneys with ≥20% GS were older, had higher serum creatinine values at 1 and 2 years, but similar rates of delayed graft function and 2-year graft survival. Vasculopathy did not correlate to any important donor criteria except the percent GS. However, serum creatinine was significantly higher in recipients of kidneys with moderate vasculopathy versus none, up to 2 years after transplantation. There was no significant difference in graft loss based upon vasculopathy. CONCLUSIONS: Kidneys from donors with ≥20% GS provide excellent outcome similar to kidneys from donors with no GS.

UR - http://www.scopus.com/inward/record.url?scp=0034467336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034467336&partnerID=8YFLogxK

U2 - 10.1016/S0002-9610(00)00502-X

DO - 10.1016/S0002-9610(00)00502-X

M3 - Article

VL - 180

SP - 470

EP - 474

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 6

ER -