Severe systemic hypersensitivity reaction to ibuprofen: A presentation of systemic lupus erythematosus

Steven S. Mou, Lynn Punaro, Jordi Antón, Peter M. Luckett

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We describe the first severe systemic hypersensitivity reaction to ibuprofen in a pediatric patient with previously undiagnosed systemic lupus erythematosus (SLE). An 11-year-old Thai male presented with fever, rash, altered mental status, and hypotension after oral administration of ibuprofen leading to the diagnosis of SLE. Re-dosing with ibuprofen resulted in recurrence of presenting symptoms. Severe hypersensitivity with hypotension can be a rare consequence of the use of ibuprofen in children with collagen vascular disease. When encountered in an otherwise healthy child, a high index of suspicion must be maintained for the diagnosis of SLE.

Original languageEnglish (US)
Pages (from-to)171-172
Number of pages2
JournalJournal of Rheumatology
Volume33
Issue number1
StatePublished - Jan 1 2006

Keywords

  • Collagen vascular disease
  • Ibuprofen
  • Pediatrics
  • Severe hypersensitivity reaction
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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