Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research

Eugenia Morselli; Aaron P. Frank; Roberta S. Santos; Luciana A. Fátima; Biff F. Palmer; Deborah J. Clegg

doi:10.1016/j.cmet.2016.07.017

Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research

Eugenia Morselli, Aaron P. Frank, Roberta S. Santos, Luciana A. Fátima, Biff F. Palmer, Deborah J. Clegg

Research output: Contribution to journal › Comment/debate › peer-review

34 Scopus citations

Abstract

In this Essay, we discuss the critical need to incorporate sex and gender in pre-clinical and clinical research to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender. This knowledge will allow for development of personalized medicine which will optimize therapies specific for individuals.

Original language	English (US)
Pages (from-to)	203-209
Number of pages	7
Journal	Cell Metabolism
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2016.07.017
State	Published - Aug 9 2016

Keywords

cardiovascular diseases
chromosome
estrogens
gender
obesity
sex
testosterone
type 2 diabetes

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2016.07.017

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title = "Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research",

abstract = "In this Essay, we discuss the critical need to incorporate sex and gender in pre-clinical and clinical research to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender. This knowledge will allow for development of personalized medicine which will optimize therapies specific for individuals.",

keywords = "cardiovascular diseases, chromosome, estrogens, gender, obesity, sex, testosterone, type 2 diabetes",

author = "Eugenia Morselli and Frank, {Aaron P.} and Santos, {Roberta S.} and F{\'a}tima, {Luciana A.} and Palmer, {Biff F.} and Clegg, {Deborah J.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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doi = "10.1016/j.cmet.2016.07.017",

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AU - Morselli, Eugenia

AU - Frank, Aaron P.

AU - Santos, Roberta S.

AU - Fátima, Luciana A.

AU - Palmer, Biff F.

AU - Clegg, Deborah J.

PY - 2016/8/9

Y1 - 2016/8/9

N2 - In this Essay, we discuss the critical need to incorporate sex and gender in pre-clinical and clinical research to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender. This knowledge will allow for development of personalized medicine which will optimize therapies specific for individuals.

AB - In this Essay, we discuss the critical need to incorporate sex and gender in pre-clinical and clinical research to enhance our understanding of the mechanisms by which metabolic processes differ by sex and gender. This knowledge will allow for development of personalized medicine which will optimize therapies specific for individuals.

KW - cardiovascular diseases

KW - chromosome

KW - estrogens

KW - gender

KW - obesity

KW - sex

KW - testosterone

KW - type 2 diabetes

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Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research

Abstract

Keywords

ASJC Scopus subject areas

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