Sex chromosome disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sex chromosome disorders have held a special fascination for geneticists and endocrinologists because of the intimate association between the sex chromosomes, germ cells, and sex determination. Molecular studies are beginning to yield explanations for phenotypes associated with sex chromosome abnormalities, such as sex reversal with Yp deletions or Xp duplications, azoospermia with Yq deletions, and short stature in Turner syndrome. Even with completion of the human genome sequence, sex chromosome disorders remain a fertile topic for research in molecular medicine.

Original languageEnglish (US)
Title of host publicationPrinciples of Molecular Medicine
PublisherHumana Press
Pages446-452
Number of pages7
ISBN (Print)9781588292025
DOIs
StatePublished - Dec 1 2006

Keywords

  • Azoospermia
  • Klinefelter syndrome
  • Turner syndrome
  • Xp duplications
  • Yp deletions
  • gonadal dysgenesis
  • sex chromosome disorders

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Zinn, A. R. (2006). Sex chromosome disorders. In Principles of Molecular Medicine (pp. 446-452). Humana Press. https://doi.org/10.1007/978-1-59259-963-9_42