Short sleep duration is associated with decreased serum leptin, increased energy intake and decreased diet quality in postmenopausal women

Jennifer H. Stern, Andriene S. Grant, Cynthia A. Thomson, Lesley Tinker, Lauren Hale, Kathleen M. Brennan, Nancy F. Woods, Zhao Chen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective Short sleep duration induces hormonal perturbations contributing to hyperphagia, insulin resistance, and obesity. The majority of these studies are conducted in young adults. This analysis in a large (n = 769) sample of postmenopausal women (median age 63 years) sought to (a) confirm that sleep duration and sleep quality are negatively correlated with circulating leptin concentrations and (b) to examine the relationship between self-reported sleep, dietary energy intake, and diet quality, as well as, investigate the role of leptin in these associations. Methods Sleep duration/quality, insomnia, and dietary intake were determined via self-report. Blood samples were collected following an overnight fast to assess serum leptin concentration. All analyses were adjusted for total body fat mass. Results Women reporting ≤6 hr sleep/night had lower serum leptin concentrations than those reporting ≥8 hr sleep (P = 0.04). Furthermore, those with ≤6 hr sleep/night reported higher dietary energy intake (P = 0.01) and lower diet quality (P = 0.04) than the reference group (7 hr sleep/night). Women sleeping ≥8 hr also reported lower diet quality than the reference group (P = 0.02). Importantly, serum leptin did not confound these associations. Conclusions These results provide evidence that sleep duration is inversely associated with serum leptin and dietary energy intake in postmenopausal women.

Original languageEnglish (US)
JournalObesity
Volume22
Issue number5
DOIs
StatePublished - Jan 1 2014

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Leptin
Energy Intake
Sleep
Diet
Serum
Hyperphagia
Sleep Initiation and Maintenance Disorders
Self Report
Insulin Resistance
Adipose Tissue
Young Adult
Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Short sleep duration is associated with decreased serum leptin, increased energy intake and decreased diet quality in postmenopausal women. / Stern, Jennifer H.; Grant, Andriene S.; Thomson, Cynthia A.; Tinker, Lesley; Hale, Lauren; Brennan, Kathleen M.; Woods, Nancy F.; Chen, Zhao.

In: Obesity, Vol. 22, No. 5, 01.01.2014.

Research output: Contribution to journalArticle

Stern, Jennifer H. ; Grant, Andriene S. ; Thomson, Cynthia A. ; Tinker, Lesley ; Hale, Lauren ; Brennan, Kathleen M. ; Woods, Nancy F. ; Chen, Zhao. / Short sleep duration is associated with decreased serum leptin, increased energy intake and decreased diet quality in postmenopausal women. In: Obesity. 2014 ; Vol. 22, No. 5.
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