Signaling pathways of cbl-b and its role in peripheral t cell tolerance

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The E3 ubiquitin ligase Cbl-b acts as a key regulator of T cell activation and peripheral tolerance. Cbl-b deficiency uncouples the requirement of CD28 costimulation for T cell activation and exhibits resistance to T cell anergy and tolerance. Cbl-bmice are highly susceptible to autoimmune diseases. Conversely, they mount a robust antitumor response resulting in spontaneous tumor rejection. Therefore, modulation of Cbl-b might provide a unique opportunity for immunotherapeutic strategies for inflammatory disorders, including autoimmunity and cancer.

Original languageEnglish (US)
Title of host publicationTrends in Stem Cell Proliferation and Cancer Research
PublisherSpringer Netherlands
Pages195-203
Number of pages9
ISBN (Electronic)9789400762114
ISBN (Print)9789400762107
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • Anergy
  • Cbl-b
  • Regulatory T cells
  • Tolerance
  • Ubiquitination

ASJC Scopus subject areas

  • Medicine(all)

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