Significant CD5 expression on normal stage 3 hematogones and mature B lymphocytes in bone marrow

Franklin S. Fuda, Nitin J. Karandikar, Weina Chen

Research output: Contribution to journalArticle

15 Scopus citations


B-cell maturation from hematogones to mature B cells in bone marrow exhibits a consistent, complex spectrum of sequential antigen expression. CD5 expression, however, has not been characterized. We studied the dynamics of CD5 expression on developing B cells by 4-color flow cytometry in 32 patients, aged 9 months to 63 years, with hematogone hyperplasia (>3.5% of total events). The mean percentage of hematogones was 8.1%. We demonstrate consistent CD5 expression on normal, polytypic B cells in a continuum, predominantly at later stages of maturation, specifically on stage 3 hematogones and mature B cells. Awareness of this normal pattern of CD5 expression on B-cell subsets has implications in the analysis of minimal residual disease of CD5+ B-lineage non-Hodgkin lymphomas.

Original languageEnglish (US)
Pages (from-to)733-737
Number of pages5
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - Dec 2 2009



  • CD5
  • Hematogones
  • Mature B cells
  • Multiparameter flow cytometry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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