Simultaneous multi-slice (SMS) acquisition enhances the sensitivity of hemodynamic mapping using gas challenges

Harshan Ravi, Peiying Liu, Shin Lei Peng, Hanli Liu, Hanzhang Lu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hemodynamic mapping using gas inhalation has received increasing interest in recent years. Cerebrovascular reactivity (CVR), which reflects the ability of the brain vasculature to dilate in response to a vasoactive stimulus, can be measured by CO2 inhalation with continuous acquisition of blood oxygen level-dependent (BOLD) magnetic resonance images. Cerebral blood volume (CBV) can be measured by O2 inhalation. These hemodynamic mapping methods are appealing because of their absence of gadolinium contrast agent, their ability to assess both baseline perfusion and vascular reserve, and their utility in calibrating the functional magnetic resonance imaging (fMRI) signal. However, like other functional and physiological indices, a major drawback of these measurements is their poor sensitivity and reliability. Simultaneous multi-slice echo planar imaging (SMS EPI) is a fast imaging technology that allows the excitation and acquisition of multiple two-dimensional slices simultaneously, and has been shown to enhance the sensitivity of several MRI applications. To our knowledge, the benefit of SMS in gas inhalation imaging has not been investigated. In this work, we compared the sensitivity of CO2 and O2 inhalation data collected using SMS factor 2 (SMS2) and SMS factor 3 (SMS3) with those collected using conventional EPI (SMS1). We showed that the sensitivity of SMS scans was significantly (p = 0.01) higher than that of conventional EPI, although no difference was found between SMS2 and SMS3 (p = 0.3). On a voxel-wise level, approximately 20–30% of voxels in the brain showed a significant enhancement in sensitivity when using SMS compared with conventional EPI, with other voxels showing an increase, but not reaching statistical significance. When using SMS, the scan duration can be reduced by half, whilst maintaining the sensitivity of conventional EPI. The availability of a sensitive acquisition technique can further enhance the potential of gas inhalation MRI in clinical applications.

Original languageEnglish (US)
Pages (from-to)1511-1518
Number of pages8
JournalNMR in Biomedicine
Volume29
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Hemodynamics
Inhalation
Gases
Imaging techniques
Magnetic resonance imaging
Brain
Blood
Gadolinium
Magnetic resonance
Contrast Media
Availability
Oxygen
Echo-Planar Imaging
Blood Vessels
Magnetic Resonance Spectroscopy
Perfusion
Magnetic Resonance Imaging
Technology

Keywords

  • brain
  • cerebrovascular reactivity
  • CO
  • gas inhalation
  • MRI
  • SMS

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

Cite this

Simultaneous multi-slice (SMS) acquisition enhances the sensitivity of hemodynamic mapping using gas challenges. / Ravi, Harshan; Liu, Peiying; Peng, Shin Lei; Liu, Hanli; Lu, Hanzhang.

In: NMR in Biomedicine, Vol. 29, No. 11, 01.11.2016, p. 1511-1518.

Research output: Contribution to journalArticle

Ravi, Harshan ; Liu, Peiying ; Peng, Shin Lei ; Liu, Hanli ; Lu, Hanzhang. / Simultaneous multi-slice (SMS) acquisition enhances the sensitivity of hemodynamic mapping using gas challenges. In: NMR in Biomedicine. 2016 ; Vol. 29, No. 11. pp. 1511-1518.
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