Single-dose cefmetazole versus cefotetan prophylaxis for cesarean section and vaginal hysterectomy

S. M. Ramin, S. M. Cox, D. L. Hemsell, L. C. Gilstrap

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While numerous antimicrobial agents are available today for prophylaxis during pelvic surgery, there is no consensus of opinion as to the ideal agent. The present study compared single-dose cefmetazole to cefotetan prophylaxis for cesarean section and vaginal hysterectomy. Of the 165 evaluable patients, 82 were given cefmetazole and 83 were given cefotetan. Although more patients (21.2%) receiving cefmetazole in the cesarean section group experienced clinical failure than in the cefotetan group (12.9%), this difference was not statistically significant (p=0.4). Only 1 woman given cefotetan developed infection after hysterectomy. The overall clinical success rates were similar for cefmetazole and cefotetan (91% versus 94%). There were no significant untoward clinical or laboratory side effects with either regimen. We conclude that cefmetazole and cefotetan are both safe and effective prophylactic agents in the prevention of postoperative female pelvic infections.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalAdvances in Therapy
Issue number3
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Medicine(all)

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