Single-walled carbon nanotube-mediated small interfering RNA delivery for Gastrin-releasing peptide receptor silencing in human neuroblastoma

Jingbo Qiao, Tu Hong, Honglian Guo, Ya Qiong Xu, Dai H. Chung

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Small interfering RNA (siRNA) has the potential to influence gene expression with a high degree of target gene specificity. However, the clinical application of siRNA therapeutics has proven to be less promising as evidenced by its poor intracellular uptake, instability in vivo, and nonspecific immune stimulations. Recently, we have demonstrated that single-walled carbon nanotube (SWNT)-mediated siRNA delivery can enhance the efficiency of siRNA-mediated gastrin-releasing peptide receptor (GRP-R) gene silencing by stabilizing siRNA while selectively targeting tumor tissues. Based on our recent findings, we introduce a novel technique to silence specific gene(s) in human neuroblastoma through SWNT-mediated siRNA delivery in vitro and in vivo.

Original languageEnglish (US)
Title of host publicationNanoBiotechnology Protocols
Pages137-147
Number of pages11
DOIs
StatePublished - Sep 3 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1026
ISSN (Print)1064-3745

Keywords

  • Delivery
  • GRP-R
  • Image
  • Neuroblastoma
  • SWNT
  • siRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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