TY - GEN
T1 - Singlet oxygen dosimetry modeling for photodynamic therapy
AU - Liang, Xing
AU - Wang, Ken Kang Hsin
AU - Zhu, Timothy C.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Photodynamic therapy (PDT) is an important treatment modality for cancer and other localized diseases. In addition to PDT dose, singlet oxygen ( 1O 2) concentration is used as an explicit PDT dosimetry quantity, because 1O 2 is the major cytotoxic agent in photodynamic therapy, and the reaction between 1O 2 and tumor tissues/cells determines the treatment efficacy. 1O 2 concentration can be obtained by the PDT model, which includes diffusion equation for the light transport in tissue and macroscopic kinetic equations for the generation of the singlet oxygen. This model was implemented using finite-element method (FEM) by COMSOL. In the kinetic equations, 5 photo-physiological parameters were determined explicitly to predict the generation of 1O 2. The singlet oxygen concentration profile was calculated iteratively by comparing the model with the measurements based on mice experiments, to obtain the apparent reacted 1O 2 concentration as an explicit PDT dosimetry quantity. Two photosensitizers including Photofrin and BPD Verteporfin, were tested using this model to determine their photo-physiological parameters and the reacted 1O 2 concentrations.
AB - Photodynamic therapy (PDT) is an important treatment modality for cancer and other localized diseases. In addition to PDT dose, singlet oxygen ( 1O 2) concentration is used as an explicit PDT dosimetry quantity, because 1O 2 is the major cytotoxic agent in photodynamic therapy, and the reaction between 1O 2 and tumor tissues/cells determines the treatment efficacy. 1O 2 concentration can be obtained by the PDT model, which includes diffusion equation for the light transport in tissue and macroscopic kinetic equations for the generation of the singlet oxygen. This model was implemented using finite-element method (FEM) by COMSOL. In the kinetic equations, 5 photo-physiological parameters were determined explicitly to predict the generation of 1O 2. The singlet oxygen concentration profile was calculated iteratively by comparing the model with the measurements based on mice experiments, to obtain the apparent reacted 1O 2 concentration as an explicit PDT dosimetry quantity. Two photosensitizers including Photofrin and BPD Verteporfin, were tested using this model to determine their photo-physiological parameters and the reacted 1O 2 concentrations.
KW - Photodynamic therapy
KW - Photosensitizer
KW - Singlet oxygen concentration
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U2 - 10.1117/12.908317
DO - 10.1117/12.908317
M3 - Conference contribution
C2 - 26005246
AN - SCOPUS:84859322284
SN - 9780819488534
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Methods for Tumor Treatment and Detection
T2 - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI
Y2 - 21 January 2012 through 22 January 2012
ER -