Sjögren's syndrome

A condition with features of chronic graft-versus-host disease: Does duct cell adhesion or permeability play a role in pathogenesis?

P. J. Lamey, F. T. Lundy, I. Al-Hashimi

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Primary and Secondary Sjögren's syndrome are disease complexes characterized by periductal inflammatory cell infiltration of the salivary and lacrimal glands and manifest as dry mouth and dry eyes. Secondary Sjögren's syndrome may be associated with a connective tissue disorder. Additional extraglandular features in Sjögren's syndrome include a generalized inflammatory exocrinopathy that might be associated with abnormalities of both humoral and cellular mediated immunity. Similar inflammatory changes and extraglandular features, including an altered immune response, have been reported in patients developing graft-versus-host disease after bone-marrow transplantation and in patients with primary biliary cirrhosis. The periductal nature of the inflammatory response involving minor salivary and other glands raises the possibility of altered duct cell adhesion or permeability in playing a role in the aetiopathogenesis of Sjögren's syndrome. The paper pulls together evidence that could be interpreted in this light. Evidence for bacterial or viral factor(s) altering the antigenicity of the histocompartibility (HC) complex on ductal cells in Sjögren's syndrome patients is also described. A hypothesis is proposed for Sjögren's syndrome in which the principal feature is an alteration in salivary gland duct cell adhesion or permeability. A re-evaluation of current knowledge of these two conditions from a clinical and experimental context are interpreted in this light.

Original languageEnglish (US)
Pages (from-to)825-829
Number of pages5
JournalMedical Hypotheses
Volume62
Issue number5
DOIs
StatePublished - Jan 1 2004

Fingerprint

Graft vs Host Disease
Cell Adhesion
Permeability
Salivary Glands
Salivary Ducts
Minor Salivary Glands
Lacrimal Apparatus
Biliary Liver Cirrhosis
Bone Marrow Transplantation
Cellular Immunity
Connective Tissue
Mouth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sjögren's syndrome : A condition with features of chronic graft-versus-host disease: Does duct cell adhesion or permeability play a role in pathogenesis? / Lamey, P. J.; Lundy, F. T.; Al-Hashimi, I.

In: Medical Hypotheses, Vol. 62, No. 5, 01.01.2004, p. 825-829.

Research output: Contribution to journalReview article

@article{13ce9f0a1d824673b0d6e0bbf3d10d44,
title = "Sj{\"o}gren's syndrome: A condition with features of chronic graft-versus-host disease: Does duct cell adhesion or permeability play a role in pathogenesis?",
abstract = "Primary and Secondary Sj{\"o}gren's syndrome are disease complexes characterized by periductal inflammatory cell infiltration of the salivary and lacrimal glands and manifest as dry mouth and dry eyes. Secondary Sj{\"o}gren's syndrome may be associated with a connective tissue disorder. Additional extraglandular features in Sj{\"o}gren's syndrome include a generalized inflammatory exocrinopathy that might be associated with abnormalities of both humoral and cellular mediated immunity. Similar inflammatory changes and extraglandular features, including an altered immune response, have been reported in patients developing graft-versus-host disease after bone-marrow transplantation and in patients with primary biliary cirrhosis. The periductal nature of the inflammatory response involving minor salivary and other glands raises the possibility of altered duct cell adhesion or permeability in playing a role in the aetiopathogenesis of Sj{\"o}gren's syndrome. The paper pulls together evidence that could be interpreted in this light. Evidence for bacterial or viral factor(s) altering the antigenicity of the histocompartibility (HC) complex on ductal cells in Sj{\"o}gren's syndrome patients is also described. A hypothesis is proposed for Sj{\"o}gren's syndrome in which the principal feature is an alteration in salivary gland duct cell adhesion or permeability. A re-evaluation of current knowledge of these two conditions from a clinical and experimental context are interpreted in this light.",
author = "Lamey, {P. J.} and Lundy, {F. T.} and I. Al-Hashimi",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.mehy.2003.12.025",
language = "English (US)",
volume = "62",
pages = "825--829",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",
number = "5",

}

TY - JOUR

T1 - Sjögren's syndrome

T2 - A condition with features of chronic graft-versus-host disease: Does duct cell adhesion or permeability play a role in pathogenesis?

AU - Lamey, P. J.

AU - Lundy, F. T.

AU - Al-Hashimi, I.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Primary and Secondary Sjögren's syndrome are disease complexes characterized by periductal inflammatory cell infiltration of the salivary and lacrimal glands and manifest as dry mouth and dry eyes. Secondary Sjögren's syndrome may be associated with a connective tissue disorder. Additional extraglandular features in Sjögren's syndrome include a generalized inflammatory exocrinopathy that might be associated with abnormalities of both humoral and cellular mediated immunity. Similar inflammatory changes and extraglandular features, including an altered immune response, have been reported in patients developing graft-versus-host disease after bone-marrow transplantation and in patients with primary biliary cirrhosis. The periductal nature of the inflammatory response involving minor salivary and other glands raises the possibility of altered duct cell adhesion or permeability in playing a role in the aetiopathogenesis of Sjögren's syndrome. The paper pulls together evidence that could be interpreted in this light. Evidence for bacterial or viral factor(s) altering the antigenicity of the histocompartibility (HC) complex on ductal cells in Sjögren's syndrome patients is also described. A hypothesis is proposed for Sjögren's syndrome in which the principal feature is an alteration in salivary gland duct cell adhesion or permeability. A re-evaluation of current knowledge of these two conditions from a clinical and experimental context are interpreted in this light.

AB - Primary and Secondary Sjögren's syndrome are disease complexes characterized by periductal inflammatory cell infiltration of the salivary and lacrimal glands and manifest as dry mouth and dry eyes. Secondary Sjögren's syndrome may be associated with a connective tissue disorder. Additional extraglandular features in Sjögren's syndrome include a generalized inflammatory exocrinopathy that might be associated with abnormalities of both humoral and cellular mediated immunity. Similar inflammatory changes and extraglandular features, including an altered immune response, have been reported in patients developing graft-versus-host disease after bone-marrow transplantation and in patients with primary biliary cirrhosis. The periductal nature of the inflammatory response involving minor salivary and other glands raises the possibility of altered duct cell adhesion or permeability in playing a role in the aetiopathogenesis of Sjögren's syndrome. The paper pulls together evidence that could be interpreted in this light. Evidence for bacterial or viral factor(s) altering the antigenicity of the histocompartibility (HC) complex on ductal cells in Sjögren's syndrome patients is also described. A hypothesis is proposed for Sjögren's syndrome in which the principal feature is an alteration in salivary gland duct cell adhesion or permeability. A re-evaluation of current knowledge of these two conditions from a clinical and experimental context are interpreted in this light.

UR - http://www.scopus.com/inward/record.url?scp=1942436033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1942436033&partnerID=8YFLogxK

U2 - 10.1016/j.mehy.2003.12.025

DO - 10.1016/j.mehy.2003.12.025

M3 - Review article

VL - 62

SP - 825

EP - 829

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 5

ER -