TY - JOUR
T1 - Sleep after TBI
T2 - How the TBI Model Systems have advanced the field
AU - Bell, Kathleen R
AU - Bushnik, Tamara
AU - Dams-O'Connor, Kristen
AU - Goldin, Yelena
AU - Hoffman, Jeanne M.
AU - Lequerica, Anthony H.
AU - Nakase-Richardson, Risa
AU - Zumsteg, Jennifer M.
N1 - Funding Information:
To date, over 16,000 subjects have been entered to date in the civilian TBIMS with outcomes available over 30 years. The VA PRCs have enrolled over 1100 subjects with outcomes available over the first 5-years. More than 850 peer-reviewed publications have derived from the longitudinal database and the single-and multi-site research projects that have been funded from this grant program; please see the TBIMS National Data and Statistical Center website (TBIMS NDSC)(NDSC, 2018b)). Additionally, an emphasis has been placed on the dissemination of information to both the scientific and medical communities and to consumers through the Model Systems Knowledge Translation Center (MSKTC) (MSKTC, 2018). The existence of the longitudinal database infrastructure has permitted the funding of a number of other large multicenter research trials funded by other agencies, such as the Patient-Centered Outcomes Research Institute (PCORI).
PY - 2018
Y1 - 2018
N2 - Background: Identification and management of comorbidities in TBI has become an increasing focus for optimizing TBI outcomes. Recent meta-analyses highlight sleep disturbance and sleep disorders following TBI (Mathias & Alvaro, 2012). Improving the recognition and treatment of sleep disorders in TBI should be a central focus of rehabilitation. The Traumatic Brain Injury Model System (TBIMS) has created an infrastructure allowing multi-center investigations into sleep dysfunction in those who have had a moderate to severe TBI and received inpatient rehabilitation. Objective: This paper will describe the 1) infrastructure used to advance sleep dysfunction/disorders research following TBI, 2) preliminary findings from these studies, and 3) repository of data which can be accessed for secondary analyses by investigators outside of the TBIMS infrastructure. Methods: Two internal mechanisms allow investigators at TBIMS sites to collaborate on projects of shared interest: Research Modules and Special Interest Groups (SIG). Results: To date, five studies have resulted from the TBIMS collaborative process focusing on insomnia, circadian disruption, and sleep apnea. Conclusions: Future directions for the SIG include continued development of available knowledge and understanding of the multidimensional factors that contribute to TBI-related sleep disturbance, optimal assessment tools, effectiveness of available treatments, and treatment compliance in this population.
AB - Background: Identification and management of comorbidities in TBI has become an increasing focus for optimizing TBI outcomes. Recent meta-analyses highlight sleep disturbance and sleep disorders following TBI (Mathias & Alvaro, 2012). Improving the recognition and treatment of sleep disorders in TBI should be a central focus of rehabilitation. The Traumatic Brain Injury Model System (TBIMS) has created an infrastructure allowing multi-center investigations into sleep dysfunction in those who have had a moderate to severe TBI and received inpatient rehabilitation. Objective: This paper will describe the 1) infrastructure used to advance sleep dysfunction/disorders research following TBI, 2) preliminary findings from these studies, and 3) repository of data which can be accessed for secondary analyses by investigators outside of the TBIMS infrastructure. Methods: Two internal mechanisms allow investigators at TBIMS sites to collaborate on projects of shared interest: Research Modules and Special Interest Groups (SIG). Results: To date, five studies have resulted from the TBIMS collaborative process focusing on insomnia, circadian disruption, and sleep apnea. Conclusions: Future directions for the SIG include continued development of available knowledge and understanding of the multidimensional factors that contribute to TBI-related sleep disturbance, optimal assessment tools, effectiveness of available treatments, and treatment compliance in this population.
KW - Sleep disorders
KW - sleep dysfunction
KW - traumatic brain injury
KW - traumatic brain injury model systems
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U2 - 10.3233/NRE-182538
DO - 10.3233/NRE-182538
M3 - Article
C2 - 30347631
AN - SCOPUS:85056397701
SN - 1053-8135
VL - 43
SP - 287
EP - 296
JO - NeuroRehabilitation
JF - NeuroRehabilitation
IS - 3
ER -