Sleep-wake patterns of seizures in children with lesional epilepsy

Joseph Kaleyias, Tobias Loddenkemper, Martina Vendrame, Rohit Das, Tanvir U. Syed, Andreas V. Alexopoulos, Elaine Wyllie, Sanjeev V. Kothare

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study examined diurnal patterns of seizures and their occurrence during wakefulness and sleep in children with lesional focal epilepsy. We reviewed 332 consecutive children with lesional focal epilepsy and video-electroencephalogram monitoring during a 3-year period. Data were analyzed in relationship to clock time, wakefulness/sleep, and seizure localization. The distribution of lesions in 66 children (259 seizures) included mesial temporal, 29%; neocortical temporal, 18%; frontal, 29%; parietal, 13.5%; and occipital, 12%. Seizures in patients with frontal lesions occurred mostly during sleep (72%). Seizures in mesial temporal (64%), neocortical temporal (71%), and occipital (66%) lesional epilepsy occurred mostly during wakefulness. Temporal lobe seizures occurred more frequently during wakefulness (66%), compared with extratemporal seizures (32%) (odds ratio, 2.67; 95% confidence interval, 1.61-4.42). Temporal lobe seizures peaked between 9:00 am and noon and 3:00-6:00 pm, whereas extratemporal seizures peaked between 6:00-9:00 am. Sleep, not clock time, provides a more robust stimulus for seizure onset, especially for frontal lobe seizures. Temporal lobe seizures are more frequent during wakefulness than are extratemporal seizures. Circadian patterns of seizures may provide additional diagnostic and treatment options, such as differential medication dosing and sleep-schedule adjustments.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalPediatric Neurology
Volume45
Issue number2
DOIs
StatePublished - Aug 1 2011

Fingerprint

Epilepsy
Sleep
Seizures
Wakefulness
Temporal Lobe
Partial Epilepsy
Social Adjustment
Frontal Lobe
Electroencephalography
Appointments and Schedules
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Kaleyias, J., Loddenkemper, T., Vendrame, M., Das, R., Syed, T. U., Alexopoulos, A. V., ... Kothare, S. V. (2011). Sleep-wake patterns of seizures in children with lesional epilepsy. Pediatric Neurology, 45(2), 109-113. https://doi.org/10.1016/j.pediatrneurol.2011.03.006

Sleep-wake patterns of seizures in children with lesional epilepsy. / Kaleyias, Joseph; Loddenkemper, Tobias; Vendrame, Martina; Das, Rohit; Syed, Tanvir U.; Alexopoulos, Andreas V.; Wyllie, Elaine; Kothare, Sanjeev V.

In: Pediatric Neurology, Vol. 45, No. 2, 01.08.2011, p. 109-113.

Research output: Contribution to journalArticle

Kaleyias, J, Loddenkemper, T, Vendrame, M, Das, R, Syed, TU, Alexopoulos, AV, Wyllie, E & Kothare, SV 2011, 'Sleep-wake patterns of seizures in children with lesional epilepsy', Pediatric Neurology, vol. 45, no. 2, pp. 109-113. https://doi.org/10.1016/j.pediatrneurol.2011.03.006
Kaleyias J, Loddenkemper T, Vendrame M, Das R, Syed TU, Alexopoulos AV et al. Sleep-wake patterns of seizures in children with lesional epilepsy. Pediatric Neurology. 2011 Aug 1;45(2):109-113. https://doi.org/10.1016/j.pediatrneurol.2011.03.006
Kaleyias, Joseph ; Loddenkemper, Tobias ; Vendrame, Martina ; Das, Rohit ; Syed, Tanvir U. ; Alexopoulos, Andreas V. ; Wyllie, Elaine ; Kothare, Sanjeev V. / Sleep-wake patterns of seizures in children with lesional epilepsy. In: Pediatric Neurology. 2011 ; Vol. 45, No. 2. pp. 109-113.
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