Smad10 is required for formation of the frog nervous system

James A. LeSueur, Edgardo S. Fortuno, Renée M. McKay, Jonathan M. Graff

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Before the nervous system establishes its complex array of cell types and connections, multipotent cells are instructed to adopt a neural fate and an anterior-posterior pattern is established. In this report, we show that Smad10, a member of the Smad family of intracellular transducers of TGFβ signaling, is required for formation of the nervous system. In addition, two types of molecules proposed as key to neural induction and patterning, bone morphogenetic protein (BMP) antagonists and fibroblast growth factor (FGF), require Smad10 for these activities. These data suggest that Smad10 may be a central mediator of the development of the frog nervous system.

Original languageEnglish (US)
Pages (from-to)771-783
Number of pages13
JournalDevelopmental cell
Volume2
Issue number6
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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