Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen

Thomas M. Wilkie, Rodney A. Schmidt, Manfred Baetscher, Albee Messing

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Transgenic mice carrying the SV40 early region fused to the Drosophila hsp70 promoter developed smooth muscle and bone neoplasms. The smooth muscle tumors appeared in aged mice and were preferentially located on the muzzle or eyelids. Multiple neoplasms were often present and each appeared to be an independent proliferation. In contrast, the bone tumors typically developed in the petrous ridge and had all the features of osteogenic sarcomas, displaying distant metastasis and invasion of the brain. Cells in both types of tumors exhibited nuclear expression of SV40 T antigen. Mice homozygous for the transgene had a shorter latency for appearance of smooth muscle tumors and developed osteosarcomas more frequently than hemizygous mice. This model system implicates the cellular T antigen-binding proteins, such as Rb and p53, in the pathogenesis of bone and soft tissue neoplasms in mice.

Original languageEnglish (US)
Pages (from-to)2889-2895
Number of pages7
JournalOncogene
Volume9
Issue number10
StatePublished - Oct 1994

Fingerprint

Muscle Neoplasms
Polyomavirus Transforming Antigens
Bone Neoplasms
Transgenic Mice
Smooth Muscle
Smooth Muscle Tumor
Osteosarcoma
Bone Tissue Neoplasms
Soft Tissue Neoplasms
Neoplasms
Viral Tumor Antigens
Eyelids
Transgenes
Drosophila
Carrier Proteins
Neoplasm Metastasis
Bone and Bones
Brain

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Wilkie, T. M., Schmidt, R. A., Baetscher, M., & Messing, A. (1994). Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen. Oncogene, 9(10), 2889-2895.

Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen. / Wilkie, Thomas M.; Schmidt, Rodney A.; Baetscher, Manfred; Messing, Albee.

In: Oncogene, Vol. 9, No. 10, 10.1994, p. 2889-2895.

Research output: Contribution to journalArticle

Wilkie, TM, Schmidt, RA, Baetscher, M & Messing, A 1994, 'Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen', Oncogene, vol. 9, no. 10, pp. 2889-2895.
Wilkie TM, Schmidt RA, Baetscher M, Messing A. Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen. Oncogene. 1994 Oct;9(10):2889-2895.
Wilkie, Thomas M. ; Schmidt, Rodney A. ; Baetscher, Manfred ; Messing, Albee. / Smooth muscle and bone neoplasms in transgenic mice expressing SV40 T antigen. In: Oncogene. 1994 ; Vol. 9, No. 10. pp. 2889-2895.
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