SNAREs

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are central components of a conserved protein machinery that governs most types of intracellular membrane traffic by virtue of their ability to form tight SNARE complexes that bring two membranes together. Synaptobrevin 2, syntaxin 1, and synaptosomal associated protein of 25kDa (SNAP-25), the neuronal SNAREs that control neurotransmitter release, share common features with other members of the SNARE family that underlie a conserved membrane fusion mechanism. In addition, the neuronal SNAREs have unique properties that enable interactions with specialized components of the neurotransmitter-release machinery and contribute to the exquisite temporal and spatial regulation of Ca2+-triggered synaptic vesicle exocytosis.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages11-19
Number of pages9
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Complexin
  • Membrane fusion
  • Munc18-1
  • NSF
  • Neurotransmitter release
  • SNAP-25
  • SNAPs
  • SNAREs
  • Synaptic transmission
  • Synaptic vesicle exocytosis
  • Synaptobrevin-VAMP
  • Synaptotagmin
  • Syntaxin

ASJC Scopus subject areas

  • Neuroscience(all)

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