SNAT7 regulates mTORC1 via macropinocytosis

Delong Meng, Qianmei Yang, Mi Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Chase H. Melick, Tshering D. Lama-Sherpa, Huanyu Wang, Mariela Huerta-Rosario, Greg Urquhart, Lauren G. Zacharias, Cheryl Lewis, Ralph J. DeBerardinis, Jenna L. Jewell

Research output: Contribution to journalArticlepeer-review

Abstract

SignificanceThe mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1. We believe this research will provide valuable insight about mTORC1 biology and may uncover novel therapeutic targets for patients.

Original languageEnglish (US)
Pages (from-to)e2123261119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number20
DOIs
StatePublished - May 17 2022

Keywords

  • macropinocytosis
  • mTOR
  • SNAT7

ASJC Scopus subject areas

  • General

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