SNAT7 regulates mTORC1 via macropinocytosis

Delong Meng; Qianmei Yang; Mi Hyeon Jeong; Adna Curukovic; Shweta Tiwary; Chase H. Melick; Tshering D. Lama-Sherpa; Huanyu Wang; Mariela Huerta-Rosario; Greg Urquhart; Lauren G. Zacharias; Cheryl Lewis; Ralph J. DeBerardinis; Jenna L. Jewell

doi:10.1073/pnas.2123261119

SNAT7 regulates mTORC1 via macropinocytosis

Delong Meng, Qianmei Yang, Mi Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Chase H. Melick, Tshering D. Lama-Sherpa, Huanyu Wang, Mariela Huerta-Rosario, Greg Urquhart, Lauren G. Zacharias, Cheryl Lewis, Ralph J. DeBerardinis, Jenna L. Jewell

Research output: Contribution to journal › Article › peer-review

Abstract

SignificanceThe mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1. We believe this research will provide valuable insight about mTORC1 biology and may uncover novel therapeutic targets for patients.

Original language	English (US)
Pages (from-to)	e2123261119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	20
DOIs	https://doi.org/10.1073/pnas.2123261119
State	Published - May 17 2022

Keywords

macropinocytosis
mTOR
SNAT7

ASJC Scopus subject areas

General

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10.1073/pnas.2123261119

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Meng, D., Yang, Q., Jeong, M. H., Curukovic, A., Tiwary, S., Melick, C. H., Lama-Sherpa, T. D., Wang, H., Huerta-Rosario, M., Urquhart, G., Zacharias, L. G., Lewis, C., DeBerardinis, R. J., & Jewell, J. L. (2022). SNAT7 regulates mTORC1 via macropinocytosis. Proceedings of the National Academy of Sciences of the United States of America, 119(20), e2123261119. https://doi.org/10.1073/pnas.2123261119

Meng, D, Yang, Q, Jeong, MH, Curukovic, A, Tiwary, S, Melick, CH, Lama-Sherpa, TD, Wang, H, Huerta-Rosario, M, Urquhart, G, Zacharias, LG, Lewis, C , DeBerardinis, RJ & Jewell, JL 2022, 'SNAT7 regulates mTORC1 via macropinocytosis', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 20, pp. e2123261119. https://doi.org/10.1073/pnas.2123261119

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title = "SNAT7 regulates mTORC1 via macropinocytosis",

abstract = "SignificanceThe mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1. We believe this research will provide valuable insight about mTORC1 biology and may uncover novel therapeutic targets for patients.",

keywords = "macropinocytosis, mTOR, SNAT7",

author = "Delong Meng and Qianmei Yang and Jeong, {Mi Hyeon} and Adna Curukovic and Shweta Tiwary and Melick, {Chase H.} and Lama-Sherpa, {Tshering D.} and Huanyu Wang and Mariela Huerta-Rosario and Greg Urquhart and Zacharias, {Lauren G.} and Cheryl Lewis and DeBerardinis, {Ralph J.} and Jewell, {Jenna L.}",

year = "2022",

month = may,

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doi = "10.1073/pnas.2123261119",

language = "English (US)",

volume = "119",

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TY - JOUR

T1 - SNAT7 regulates mTORC1 via macropinocytosis

AU - Meng, Delong

AU - Yang, Qianmei

AU - Jeong, Mi Hyeon

AU - Curukovic, Adna

AU - Tiwary, Shweta

AU - Melick, Chase H.

AU - Lama-Sherpa, Tshering D.

AU - Wang, Huanyu

AU - Huerta-Rosario, Mariela

AU - Urquhart, Greg

AU - Zacharias, Lauren G.

AU - Lewis, Cheryl

AU - DeBerardinis, Ralph J.

AU - Jewell, Jenna L.

PY - 2022/5/17

Y1 - 2022/5/17

N2 - SignificanceThe mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1. We believe this research will provide valuable insight about mTORC1 biology and may uncover novel therapeutic targets for patients.

AB - SignificanceThe mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1. We believe this research will provide valuable insight about mTORC1 biology and may uncover novel therapeutic targets for patients.

KW - macropinocytosis

KW - mTOR

KW - SNAT7

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VL - 119

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

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ER -

SNAT7 regulates mTORC1 via macropinocytosis

Abstract

Keywords

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