Soft Tissue Special Issue: Adamantinoma-Like Ewing Sarcoma of the Head and Neck: A Practical Review of a Challenging Emerging Entity

Lisa M. Rooper, Justin A. Bishop

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Adamantinoma-like Ewing sarcoma (ALES) is a rare variant of Ewing sarcoma that is defined by complex epithelial differentiation, including expression of cytokeratin and p40 and frequent keratin pearl formation. In recent years, ALES has been increasingly recognized in the head and neck, where it can mimic a wide range of small round blue cell tumors and basaloid carcinomas. However, there has been persistent controversy regarding whether ALES is best classified and managed as a sarcoma or carcinoma. This review summarizes the characteristic clinical, pathologic, immunophenotypic, and molecular features of ALES with an emphasis on differential diagnosis and tumor classification.

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalHead and Neck Pathology
Volume14
Issue number1
DOIs
StatePublished - Mar 1 2020

Keywords

  • Adamantinoma-like Ewing sarcoma
  • Complex epithelial differentiation
  • Ewing sarcoma
  • EWSR1
  • FLI1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

Fingerprint Dive into the research topics of 'Soft Tissue Special Issue: Adamantinoma-Like Ewing Sarcoma of the Head and Neck: A Practical Review of a Challenging Emerging Entity'. Together they form a unique fingerprint.

  • Cite this