Soluble ST2 predicts elevated SBP in the community

Jennifer E. Ho, Martin G. Larson, Anahita Ghorbani, Susan Cheng, Ramachandran S. Vasan, Thomas J. Wang, James L. Januzzi

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with existing cardiovascular disease. ST2 and its ligand, interleukin-33 (IL-33), are expressed in endothelial cells, and may play an important role in the development of early atherosclerosis and vascular biology. We sought to investigate the association of sST2 and progression of blood pressure (BP), as well as the development of hypertension. Methods: Circulating sST2 concentrations were measured in 1834 participants (mean age 56 years, 57% women) of the community-based Framingham Offspring study. Participants were free of hypertension at baseline. Multivariable linear and logistic regression models were used to evaluate the association of sST2 concentrations and subsequent BP outcomes. Results: Higher sST2 concentrations were associated with incident hypertension over 3 years of follow-up [multivariable-Adjusted odds ratio per 1 standard deviation increase in sST2 1.22, 95% confidence interval 1.05-1.42, P=0.01]. Individuals in the upper sST2 quartile had a 2.6mmHg greater increase in SBP compared with those in the lowest quartile (P for trend across quartiles 0.002) and a 1.8mmHg greater increase in pulse pressure (P for trend 0.005). In contrast, sST2 concentrations were not associated with changes in DBP (P=0.27). Conclusion: These findings suggest that sST2 concentrations predict changes in BP physiology typically seen with aging and progressive arterial stiffness. Further studies are needed to elucidate underlying mechanisms by which the ST2/IL-33 pathway may contribute to BP physiology.

Original languageEnglish (US)
Pages (from-to)1431-1436
Number of pages6
JournalJournal of hypertension
Volume31
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • Biological markers
  • Blood pressure
  • Epidemiology
  • Hypertension
  • Immune system
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Soluble ST2 predicts elevated SBP in the community'. Together they form a unique fingerprint.

  • Cite this

    Ho, J. E., Larson, M. G., Ghorbani, A., Cheng, S., Vasan, R. S., Wang, T. J., & Januzzi, J. L. (2013). Soluble ST2 predicts elevated SBP in the community. Journal of hypertension, 31(7), 1431-1436. https://doi.org/10.1097/HJH.0b013e3283611bdf