Solution NMR spectroscopy beyond 25 kDa

Lewis E. Kay, Kevin H. Gardner

Research output: Contribution to journalArticle

142 Scopus citations


Improvements in NMR instrumentation, higher magnetic field strengths, novel NMR experiments and new deuterium-labeling strategies have significantly increased the scope of structural problems that can now be addressed by solution NMR methods. To date, a number of structures of proteins of 30 kDa have been solved using multidimensional 15N,13C,2H NMR techniques, and this molecular weight limit will probably be surpassed in the near future.

Original languageEnglish (US)
Pages (from-to)722-731
Number of pages10
JournalCurrent Opinion in Structural Biology
Issue number5
Publication statusPublished - Oct 1997


ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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