Some immunoregulatory aspects of pregnancy in rats

A. E. Beer, J. R. Head, W. G. Smith, R. E. Billingham

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The success of the majority of pregnancies, despite the allograft character of the fetus, is principally due to trophoblastic mechanisms, but some ancillary immunoregulatory processes in the mother are probably also involved. In order to analyze this, adult female rats, both virgin and parous by syngeneic and allogeneic males, were grafted with skin from histoincompatible donors, and the median survival time registered and hemagglutinin assays performed. Multiple allogeneic pregnancies prolonged graft survival and impaired hemagglutinin responses. Another group of experiments, where female virgin rats were mated with allogeneic males after removal of paraaortic lymphnodes and the spleen, and then challenged by skin grafts, pointed to a role played by the lymphnodes in suppressing hemagglutinin formation. Trophoblast cones from allogeneic conceptuses were implanted beneath the renal capsule of another group of animals, and this led to a slight prolongation of the survival of subsequently grafted skin and to a moderate depression of hemagglutinin responses. Further, viable cells and serum from animals that had gone through one or more allogeneic pregnancies were transferred to normal syngeneic hosts; after skin grafting, the hemagglutinin response and graft rejection were suppressed most when spleen cells were used. The results of these experiments are discussed.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalTransplantation Proceedings
Volume8
Issue number2
StatePublished - 1976

Fingerprint

Hemagglutinins
Pregnancy
Skin
Spleen
Multiple Pregnancy
Skin Transplantation
Trophoblasts
Graft Rejection
Graft Survival
Capsules
Allografts
Fetus
Transplants
Kidney
Serum

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Beer, A. E., Head, J. R., Smith, W. G., & Billingham, R. E. (1976). Some immunoregulatory aspects of pregnancy in rats. Transplantation Proceedings, 8(2), 267-273.

Some immunoregulatory aspects of pregnancy in rats. / Beer, A. E.; Head, J. R.; Smith, W. G.; Billingham, R. E.

In: Transplantation Proceedings, Vol. 8, No. 2, 1976, p. 267-273.

Research output: Contribution to journalArticle

Beer, AE, Head, JR, Smith, WG & Billingham, RE 1976, 'Some immunoregulatory aspects of pregnancy in rats', Transplantation Proceedings, vol. 8, no. 2, pp. 267-273.
Beer AE, Head JR, Smith WG, Billingham RE. Some immunoregulatory aspects of pregnancy in rats. Transplantation Proceedings. 1976;8(2):267-273.
Beer, A. E. ; Head, J. R. ; Smith, W. G. ; Billingham, R. E. / Some immunoregulatory aspects of pregnancy in rats. In: Transplantation Proceedings. 1976 ; Vol. 8, No. 2. pp. 267-273.
@article{4a8736ac01c04cde91ffed96a5ef7902,
title = "Some immunoregulatory aspects of pregnancy in rats",
abstract = "The success of the majority of pregnancies, despite the allograft character of the fetus, is principally due to trophoblastic mechanisms, but some ancillary immunoregulatory processes in the mother are probably also involved. In order to analyze this, adult female rats, both virgin and parous by syngeneic and allogeneic males, were grafted with skin from histoincompatible donors, and the median survival time registered and hemagglutinin assays performed. Multiple allogeneic pregnancies prolonged graft survival and impaired hemagglutinin responses. Another group of experiments, where female virgin rats were mated with allogeneic males after removal of paraaortic lymphnodes and the spleen, and then challenged by skin grafts, pointed to a role played by the lymphnodes in suppressing hemagglutinin formation. Trophoblast cones from allogeneic conceptuses were implanted beneath the renal capsule of another group of animals, and this led to a slight prolongation of the survival of subsequently grafted skin and to a moderate depression of hemagglutinin responses. Further, viable cells and serum from animals that had gone through one or more allogeneic pregnancies were transferred to normal syngeneic hosts; after skin grafting, the hemagglutinin response and graft rejection were suppressed most when spleen cells were used. The results of these experiments are discussed.",
author = "Beer, {A. E.} and Head, {J. R.} and Smith, {W. G.} and Billingham, {R. E.}",
year = "1976",
language = "English (US)",
volume = "8",
pages = "267--273",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Some immunoregulatory aspects of pregnancy in rats

AU - Beer, A. E.

AU - Head, J. R.

AU - Smith, W. G.

AU - Billingham, R. E.

PY - 1976

Y1 - 1976

N2 - The success of the majority of pregnancies, despite the allograft character of the fetus, is principally due to trophoblastic mechanisms, but some ancillary immunoregulatory processes in the mother are probably also involved. In order to analyze this, adult female rats, both virgin and parous by syngeneic and allogeneic males, were grafted with skin from histoincompatible donors, and the median survival time registered and hemagglutinin assays performed. Multiple allogeneic pregnancies prolonged graft survival and impaired hemagglutinin responses. Another group of experiments, where female virgin rats were mated with allogeneic males after removal of paraaortic lymphnodes and the spleen, and then challenged by skin grafts, pointed to a role played by the lymphnodes in suppressing hemagglutinin formation. Trophoblast cones from allogeneic conceptuses were implanted beneath the renal capsule of another group of animals, and this led to a slight prolongation of the survival of subsequently grafted skin and to a moderate depression of hemagglutinin responses. Further, viable cells and serum from animals that had gone through one or more allogeneic pregnancies were transferred to normal syngeneic hosts; after skin grafting, the hemagglutinin response and graft rejection were suppressed most when spleen cells were used. The results of these experiments are discussed.

AB - The success of the majority of pregnancies, despite the allograft character of the fetus, is principally due to trophoblastic mechanisms, but some ancillary immunoregulatory processes in the mother are probably also involved. In order to analyze this, adult female rats, both virgin and parous by syngeneic and allogeneic males, were grafted with skin from histoincompatible donors, and the median survival time registered and hemagglutinin assays performed. Multiple allogeneic pregnancies prolonged graft survival and impaired hemagglutinin responses. Another group of experiments, where female virgin rats were mated with allogeneic males after removal of paraaortic lymphnodes and the spleen, and then challenged by skin grafts, pointed to a role played by the lymphnodes in suppressing hemagglutinin formation. Trophoblast cones from allogeneic conceptuses were implanted beneath the renal capsule of another group of animals, and this led to a slight prolongation of the survival of subsequently grafted skin and to a moderate depression of hemagglutinin responses. Further, viable cells and serum from animals that had gone through one or more allogeneic pregnancies were transferred to normal syngeneic hosts; after skin grafting, the hemagglutinin response and graft rejection were suppressed most when spleen cells were used. The results of these experiments are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0017162489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017162489&partnerID=8YFLogxK

M3 - Article

C2 - 779183

AN - SCOPUS:0017162489

VL - 8

SP - 267

EP - 273

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 2

ER -