The cause of primary (essential) hypertension remains unknown, but a number of circulating hormones and endothelium-derived factors are probably involved. This review summarizes recent evidence on the roles of hyperinsulinemia, the renin-angiotensin system, atrial natriuretic factor, and three endothelium-derived factors-prostacyclin, endothelium-derived relaxing factor, and endothelin.
- Endothelium-derived relaxing factor
- Primary hypertension
ASJC Scopus subject areas