Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus

Laurent Gautron, Michel Chaigniau, Sophie Layé

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The transcription factor STAT1 participates in signaling pathways and cellular responses triggered by several cytokines, growth factors and hormones. The present work demonstrates for the first time the immunohistochemical distribution of STAT1 in the rat hypothalamus. STAT1 immunoreactivity was observed in somas, dendrites and axons of neurons throughout the supraoptic and paraventricular nuclei and co-localized specifically with oxytocin. These findings indicate that STAT1 is positioned to participate in specific neuroendocrine regulation in the nonpathological rat brain.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalBrain Research
Volume994
Issue number2
DOIs
StatePublished - Dec 24 2003

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Keywords

  • Cytokines
  • Hypothalamus
  • Immunohistochemistry
  • Oxytocin
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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