Specificity of the bacteriophage PBS2 induced inhibitor of uracil-DNA glycosylase

Peter Karran, Richard Cone, Errol C. Friedberg

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Abstract

The purified PBS2 phage-coded inhibitor of uracil-DNA glycosylase (Ura-DNA glycosylase) from Bacillus subtilis has been tested for its ability to inhibit this enzyme isolated from other prokaryotic and from eukaryotic sources. In addition, the inhibitor has been assayed for its effect on DNA glycosylases specific for other base residues in DNA. The data indicate that Ura-DNA glycosylases from a variety of sources are equally sensitive to inhibition by the inhibitor. DNA glycosylases specific for base residues in DNA other than uracil are not inhibited by the PBS2-coded inhibitor.

Original languageEnglish (US)
Pages (from-to)6092-6096
Number of pages5
JournalBiochemistry
Volume20
Issue number21
Publication statusPublished - 1981

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ASJC Scopus subject areas

  • Biochemistry

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