Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer

Feng Yin, Mohammed Saad, Jingmei Lin, Christopher R. Jackson, Bing Ren, Cynthia Lawson, Dipti M. Karamchandani, Belen Quereda Bernabeu, Wei Jiang, Teena Dhir, Richard Zheng, Christopher W. Schultz, Dongwei Zhang, Courtney L. Thomas, Xuchen Zhang, Jinping Lai, Michael Schild, Xuefeng Zhang, Hao Xie, Xiuli Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Distal pancreatic carcinoma is one of the most lethal cancers largely due to its high incidence of distant metastasis. This study aims to assess the prognostic value of splenic-vasculature involvement in resected distal pancreatic carcinoma. Methods: In this retrospective study, we collected the clinicopathologic information of 454 patients with pancreatic cancer and performed univariate and multivariate analyses to identify factors associated with progression-free survival (PFS) and overall survival (OS), with an emphasis on the prognostic value of splenic-artery and -vein involvement. Results: Univariate analysis revealed that larger tumor size, non-intraductal papillary mucinous neoplasm (non-IPMN)-associated adenocarcinoma, poor differentiation, stage pT3, nodal metastasis, lymphovascular invasion, perineural invasion, and pathologic and radiographic evidence of splenic-vein invasion were significantly associated with shorter PFS and OS (all P < 0.05). Multivariate analysis confirmed non-IPMN-associated adenocarcinoma, stage pT3, stage pN1-2, and post-operative adjuvant chemotherapy as independent risk factors for both PFS and OS, and larger tumor size and radiographic evidence of splenic-artery invasion as predictors of PFS only. Conclusion: Guidelines should be developed for a uniform approach with regard to the examination and reporting of the status of the splenic vasculature when dealing with distal-pancreatic-cancer specimens.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalGastroenterology Report
Volume9
Issue number2
DOIs
StatePublished - Apr 1 2021
Externally publishedYes

Keywords

  • intraductal papillary mucinous neoplasm
  • pancreatic cancer
  • prognosis
  • splenic artery
  • splenic vein

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint

Dive into the research topics of 'Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer'. Together they form a unique fingerprint.

Cite this