Spontaneous corneal neovascularization in nude mice: Local imbalance between angiogenic and anti-angiogenic factors

G. M. Kaminska, J. Y. Niederkorn

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23 Scopus citations


Purpose. The present study considered the hypothesis that spontaneous neovascularization of the cornea of nude mice results from a local imbalance between angiogenic and anti-angiogenic factors. Methods. The presence of angiogenic and anti-angiogenic factors was revealed by exchanging orthotopic corneal allografts between nude BALB/c mice and normal (hirsute) euthymic BALB/c mice and observing the presence, intensity, and degree of corneal neovascularization before and after grafting. Results. Avascular corneal grafts from normal BALB/c donors resisted neovascularization after grafting to spontaneously vascularized graft beds in nude mice. In contrast, spontaneously vascularized corneal grafts from nude mice remained vascularized over 2 mo after grafting to similar nude recipients. Although corneal grafts from nude donors stimulated neovascularization in normal BALB/c recipients, most of the vessels regressed by the 6th week post transplantation. Conclusions. The results confirm that there is an imbalance between angiogenic and anti-angiogenic factors in the nude mouse cornea. The cornea of the nude mouse displays more angiogenic activity and less anti- angiogenic activity than that of the normal mouse. Most angiogenic activity of the nude mouse cornea appears to reside in the epithelium.

Original languageEnglish (US)
Pages (from-to)222-230
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Issue number1
StatePublished - Jan 1 1993



  • angiogenic factors
  • anti-angiogenic factors
  • cornea
  • neovascularization
  • nude mice

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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