TY - JOUR
T1 - State-of-the-art materials for ultrasound-triggered drug delivery
AU - Sirsi, Shashank R.
AU - Borden, Mark A.
N1 - Funding Information:
Funding for this work was provided to SRS by NIH 1R21EB015040-01A1 and to MAB by NSF grants CBET-1133687 and CBET-1059726 .
PY - 2014/6/15
Y1 - 2014/6/15
N2 - Ultrasound is a unique and exciting theranostic modality that can be used to track drug carriers, trigger drug release and improve drug deposition with high spatial precision. In this review, we briefly describe the mechanisms of interaction between drug carriers and ultrasound waves, including cavitation, streaming and hyperthermia, and how those interactions can promote drug release and tissue uptake. We then discuss the rational design of some state-of-the-art materials for ultrasound-triggered drug delivery and review recent progress for each drug carrier, focusing on the delivery of chemotherapeutic agents such as doxorubicin. These materials include nanocarrier formulations, such as liposomes and micelles, designed specifically for ultrasound-triggered drug release, as well as microbubbles, microbubble-nanocarrier hybrids, microbubble-seeded hydrogels and phase-change agents.
AB - Ultrasound is a unique and exciting theranostic modality that can be used to track drug carriers, trigger drug release and improve drug deposition with high spatial precision. In this review, we briefly describe the mechanisms of interaction between drug carriers and ultrasound waves, including cavitation, streaming and hyperthermia, and how those interactions can promote drug release and tissue uptake. We then discuss the rational design of some state-of-the-art materials for ultrasound-triggered drug delivery and review recent progress for each drug carrier, focusing on the delivery of chemotherapeutic agents such as doxorubicin. These materials include nanocarrier formulations, such as liposomes and micelles, designed specifically for ultrasound-triggered drug release, as well as microbubbles, microbubble-nanocarrier hybrids, microbubble-seeded hydrogels and phase-change agents.
KW - Liposomes
KW - Micelles
KW - Microbubbles
KW - Phase-change agents
KW - Targeted drug delivery
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U2 - 10.1016/j.addr.2013.12.010
DO - 10.1016/j.addr.2013.12.010
M3 - Review article
C2 - 24389162
AN - SCOPUS:84901602602
SN - 0169-409X
VL - 72
SP - 3
EP - 14
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -