Statin Use and Hospital Length of Stay among Adults Hospitalized with Community-acquired Pneumonia

Fiona Havers, Anna M. Bramley, Lyn Finelli, Carrie Reed, Wesley H. Self, Christopher Trabue, Sherene Fakhran, Robert Balk, D. Mark Courtney, Timothy D. Girard, Evan J. Anderson, Carlos G. Grijalva, Kathryn M. Edwards, Richard G. Wunderink, Seema Jain

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background. Prior retrospective studies suggest that statins may benefit patients with community-acquired pneumonia (CAP) due to antiinflammatory and immunomodulatory effects. However, prospective studies of the impact of statins on CAP outcomes are needed. We determined whether statin use was associated with improved outcomes in adults hospitalized with CAP. Methods. Adults aged ≥18 years hospitalized with CAP were prospectively enrolled at 3 hospitals in Chicago, Illinois, and 2 hospitals in Nashville, Tennessee, from January 2010 - June 2012. Adults receiving statins before and throughout hospitalization (statin users) were compared with those who did not receive statins (nonusers). Proportional subdistribution hazards models were used to examine the association between statin use and hospital length of stay (LOS). In-hospital mortality was a secondary outcome. We also compared groups matched on propensity score. Results. Of 2016 adults enrolled, 483 (24%) were statin users; 1533 (76%) were nonusers. Statin users were significantly older, had more comorbidities, had more years of education, and were more likely to have health insurance than nonusers. Multivariable regression demonstrated that statin users and nonusers had similar LOS (adjusted hazard ratio [HR], 0.99; 95% confidence interval [CI],. 88-1.12), as did those in the propensity-matched groups (HR, 1.03; 95% CI,. 88-1.21). No significant associations were found between statin use and LOS or in-hospital mortality, even when stratified by pneumonia severity. Conclusions. In a large prospective study of adults hospitalized with CAP, we found no evidence to suggest that statin use before and during hospitalization improved LOS or in-hospital mortality.

Original languageEnglish (US)
Pages (from-to)1471-1478
Number of pages8
JournalClinical Infectious Diseases
Volume62
Issue number12
DOIs
StatePublished - Jun 15 2016
Externally publishedYes

Keywords

  • hospitalization
  • hydroxymethylglutaryl-CoA reductase inhibitors
  • pneumonia
  • statins

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Havers, F., Bramley, A. M., Finelli, L., Reed, C., Self, W. H., Trabue, C., Fakhran, S., Balk, R., Courtney, D. M., Girard, T. D., Anderson, E. J., Grijalva, C. G., Edwards, K. M., Wunderink, R. G., & Jain, S. (2016). Statin Use and Hospital Length of Stay among Adults Hospitalized with Community-acquired Pneumonia. Clinical Infectious Diseases, 62(12), 1471-1478. https://doi.org/10.1093/cid/ciw174