Statine zur behandlung von erkrankungen des zentralen nervensystems. Eine standortbestimmung aus forschung und klinik

Translated title of the contribution: Statins for treatment of CNS diseases. Status report from research and clinical practice

T. Menge, H. C. Von Büdingen, S. S. Zamvil, H. P. Hartung, B. C. Kieseier, O. Stüve

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

3-Hydroxy-3-methyglutaryl coenzyme A (HMG-CoA) reductase inhibitors, "statins," are widely used oral cholesterol-lowering drugs. Statins competitively inhibit HMG-CoA reductase, the enzyme that catalyzes conversion of HMG-CoA to L-mevalonate, a key intermediate in cholesterol synthesis. Certain metabolites of L-mevalonate are also involved in posttranslational modifications of specific proteins with cell proliferation and differentiation properties. Thus, statins have important biologic effects beyond their cholesterol-reducing properties. Here we discuss recent experimental and clinical data that may support a potential role for statins in the treatment of three central nervous system (CNS) neurological diseases: Multiple sclerosis (MS), Alzheimer's disease (AD), and ischemic stroke. Despite their considerable pathogenic differences, in animal models of these disorders statins have shown beneficial effects. In both stroke and AD cohort studies suggest a beneficial treatment effect in humans; in MS, results from small open-label studies look encouraging. Multicenter, randomized, placebo-controlled clinical trials are in the planning or recruiting stage to evaluate the therapeutic effects of statins in all three disorders.

Translated title of the contributionStatins for treatment of CNS diseases. Status report from research and clinical practice
Original languageGerman
Pages (from-to)426-437
Number of pages12
JournalNervenarzt
Volume76
Issue number4
DOIs
StatePublished - Apr 1 2005

Keywords

  • Alzheimer's disease
  • HMG-CoA reductase inhibitors
  • Ischemic stroke
  • Multiple sclerosis
  • Statins

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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