TY - GEN
T1 - Steps towards quantification of the cardiological stress exam
AU - Chabiniok, R.
AU - Sammut, E.
AU - Hadjicharalambous, M.
AU - Asner, L.
AU - Nordsletten, D.
AU - Razav, R.
AU - Smith, N.
N1 - Funding Information:
The authors acknowledge the support of Engineering and Physical Sciences Research Council EP/H046410/1, British heart foundation grant NH/11/5/29058 and Cardiovascular Healthcare Technology Cooperative. In addition, the author are thankful to P. Moireau and D. Chapelle (Inria, France) for providing the HeartLab software library, used in this work for all modeling and estimation computations, and to D. Rueckert and W. Shi (Imperial College London, Ixico) for providing the IRTK based motion tracking and valuable discussions. This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St. Thomas’ NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.
Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - In this work we aim to advance the translation of modelbased myocardial contractility estimation to the clinical problem of quantitative assessment of the dobutamine stress exam. In particular, we address the question of limited spatial resolution of the observations obtained from cine MRI during the stress test, in which typically only a small number of cine MRI slices are acquired. Due to the relative risk during the dobutamine infusion, a safe acquisition protocol with a healthy volunteer under the infusion of a beta-blocker is applied in order to get a better insight into the contractility estimation using such a type of clinical data. The estimator is compared for three types of observations, namely the processed short axis cine stack contiguously covering the ventricles, the short axis stack limited to only 3 slices and the combination of 3 short and 3 long axis slices. A decrease of contractilities in AHA regions under the beta-blocker infusion was estimated for each observation. The corrected model (by using the estimated parameters) was then compared with the displacements extracted from 3D tagged MRI.
AB - In this work we aim to advance the translation of modelbased myocardial contractility estimation to the clinical problem of quantitative assessment of the dobutamine stress exam. In particular, we address the question of limited spatial resolution of the observations obtained from cine MRI during the stress test, in which typically only a small number of cine MRI slices are acquired. Due to the relative risk during the dobutamine infusion, a safe acquisition protocol with a healthy volunteer under the infusion of a beta-blocker is applied in order to get a better insight into the contractility estimation using such a type of clinical data. The estimator is compared for three types of observations, namely the processed short axis cine stack contiguously covering the ventricles, the short axis stack limited to only 3 slices and the combination of 3 short and 3 long axis slices. A decrease of contractilities in AHA regions under the beta-blocker infusion was estimated for each observation. The corrected model (by using the estimated parameters) was then compared with the displacements extracted from 3D tagged MRI.
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U2 - 10.1007/978-3-319-20309-6_2
DO - 10.1007/978-3-319-20309-6_2
M3 - Conference contribution
AN - SCOPUS:84949979694
SN - 9783319203089
SN - 9783319203089
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 12
EP - 20
BT - Functional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings
A2 - van Assen, Hans
A2 - Bovendeerd, Peter
A2 - van Assen, Hans
A2 - Bovendeerd, Peter
A2 - Delhaas, Tammo
A2 - Delhaas, Tammo
PB - Springer Verlag
T2 - 8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015
Y2 - 25 June 2015 through 27 June 2015
ER -