Steps towards quantification of the cardiological stress exam

R. Chabiniok, E. Sammut, M. Hadjicharalambous, L. Asner, D. Nordsletten, R. Razav, N. Smith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work we aim to advance the translation of modelbased myocardial contractility estimation to the clinical problem of quantitative assessment of the dobutamine stress exam. In particular, we address the question of limited spatial resolution of the observations obtained from cine MRI during the stress test, in which typically only a small number of cine MRI slices are acquired. Due to the relative risk during the dobutamine infusion, a safe acquisition protocol with a healthy volunteer under the infusion of a beta-blocker is applied in order to get a better insight into the contractility estimation using such a type of clinical data. The estimator is compared for three types of observations, namely the processed short axis cine stack contiguously covering the ventricles, the short axis stack limited to only 3 slices and the combination of 3 short and 3 long axis slices. A decrease of contractilities in AHA regions under the beta-blocker infusion was estimated for each observation. The corrected model (by using the estimated parameters) was then compared with the displacements extracted from 3D tagged MRI.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 8th International Conference, FIMH 2015, Proceedings
EditorsHans van Assen, Peter Bovendeerd, Hans van Assen, Peter Bovendeerd, Tammo Delhaas, Tammo Delhaas
PublisherSpringer Verlag
Pages12-20
Number of pages9
ISBN (Print)9783319203089, 9783319203089
DOIs
StatePublished - 2015
Externally publishedYes
Event8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015 - Maastricht, Netherlands
Duration: Jun 25 2015Jun 27 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9126
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other8th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2015
Country/TerritoryNetherlands
CityMaastricht
Period6/25/156/27/15

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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