Sterol regulatory element-binding proteins

Activators of cholesterol and fatty acid biosynthesis

Jay D. Horton, Lichiro Shimomura

Research output: Contribution to journalArticle

254 Citations (Scopus)

Abstract

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalCurrent Opinion in Lipidology
Volume10
Issue number2
DOIs
StatePublished - Apr 1999

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Sterol Regulatory Element Binding Proteins
Biosynthesis
Fatty Acids
Cholesterol
Liver
Transcription Factors
Genes
Feedback

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sterol regulatory element-binding proteins : Activators of cholesterol and fatty acid biosynthesis. / Horton, Jay D.; Shimomura, Lichiro.

In: Current Opinion in Lipidology, Vol. 10, No. 2, 04.1999, p. 143-150.

Research output: Contribution to journalArticle

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