Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis

Jay D. Horton, Lichiro Shimomura

Research output: Contribution to journalReview article

256 Scopus citations

Abstract

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalCurrent opinion in lipidology
Volume10
Issue number2
DOIs
StatePublished - Apr 1 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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