Abstract
The effect of (-)-OSU6162 on the incorporation of GTPgammaS35 in the membranes of hD2l-transfected CHO cells was investigated. In the absence of dopamine the compound exerted a slight but significant stimulating action, suggesting a weak partial agonism. In the presence of dopamine, low concentrations (10 to 100nM) enhanced the stimulating action of dopamine. This enhancing effect was reversed by higher concentrations of (-)-OSU6162 in a complex biphasic manner. The dopamine-enhancing action is proposed to be mediated by binding to an allosteric site with high affinity and the inhibitory component by a low-affinity binding to the orthosteric site of the dopamine receptor.
Original language | English (US) |
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Pages (from-to) | 1143-1146 |
Number of pages | 4 |
Journal | Journal of Neural Transmission |
Volume | 114 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2007 |
Keywords
- Dopamine
- GTPgammaS
- Partial dopamine agonist
- Psychosis
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry