Stimulation of prolactin and growth hormone secretion by muscimol, a γ-aminobutyric acid agonist

C. A. Tamminga, A. Neophytides, T. N. Chase, L. A. Frohman

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5). PRL levels rose significantly in a dose-dependent fashion within a 120-min time interval. GH rose significantly but modestly over the same time interval, whereas TSH and cortisol levels remained unchanged. Since muscimol is thought to be a potent and specific γ-aminobutyric acid agonist, these data indicate that γ-aminobutyric acid-mediated neural transmission may function to stimulate the release of plasma PRL and GH in human subjects.

Original languageEnglish (US)
Pages (from-to)1348-1351
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume47
Issue number6
DOIs
StatePublished - Dec 1978

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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