Abstract
The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5). PRL levels rose significantly in a dose-dependent fashion within a 120-min time interval. GH rose significantly but modestly over the same time interval, whereas TSH and cortisol levels remained unchanged. Since muscimol is thought to be a potent and specific γ-aminobutyric acid agonist, these data indicate that γ-aminobutyric acid-mediated neural transmission may function to stimulate the release of plasma PRL and GH in human subjects.
Original language | English (US) |
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Pages (from-to) | 1348-1351 |
Number of pages | 4 |
Journal | Journal of Clinical Endocrinology and Metabolism |
Volume | 47 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1978 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical