Strain distribution pattern of immune nephritis - A follow-up study

Chun Xie, Ziaur S M Rahman, Shangkui Xie, Jiankun Zhu, Yong Du, Xiangmei Qin, Hui Zhou, Xin J. Zhou, Chandra Mohan

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Previous studies have indicated that the NZW, DBA/1, 129/sv and BUB strains are particularly sensitive to experimental anti-glomerular basement membrane (GBM)-induced immune nephritis. The present study extends previous observations by examining eight additional inbred mouse strains for their susceptibility to immune nephritis. Unlike the ALR/Lt, CAST/Ei, DDY/JclSidSeyFrk, FVB/NJ, PERA/Ei, SB/Le and BALB/c strains, the C58 mouse strain was observed to be particularly susceptible to experimental immune nephritis, with CBA mice being a close second. In contrast to the other strains, C58 mice uniformly developed heavy proteinuria, azotemia and severe glomerulonephritis with prominent crescent formation and tubulointerstitial nephritis following challenge with anti-GBM sera. These differences were associated with increased murine Ig deposition, leukocyte infiltration and IFN-γ production within the kidneys of C58 mice. Studies aimed at elucidating the genetic factors and molecular pathways responsible for the enhanced renal disease in C58 mice are warranted.

Original languageEnglish (US)
Pages (from-to)719-728
Number of pages10
JournalInternational Immunology
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2008

Keywords

  • Antibodies
  • Autoimmunity
  • C58
  • Inflammation
  • Mouse models

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Xie, C., Rahman, Z. S. M., Xie, S., Zhu, J., Du, Y., Qin, X., Zhou, H., Zhou, X. J., & Mohan, C. (2008). Strain distribution pattern of immune nephritis - A follow-up study. International Immunology, 20(6), 719-728. https://doi.org/10.1093/intimm/dxn030