Strategies for organ level tissue engineering

Kristine C. Rustad, Michael Sorkin, Benjamin Levi, Michael T. Longaker, Geoffrey C. Gurtner

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

The field of tissue engineering has made considerable strides since it was first described in the late 1980s. The advent and subsequent boom in stem cell biology, emergence of novel technologies for biomaterial development, and further understanding of developmental biology have contributed to this accelerated progress. However, continued efforts to translate tissue-engineering strategies into clinical therapies have been hampered by the problems associated with scaling up laboratory methods to produce large, complex tissues. The significant challenges faced by tissue engineers include the production of an intact vasculature within a tissue-engineered construct and recapitulation of the size and complexity of a whole organ. Here we review the basic components necessary for bioengineering organs - biomaterials, cells and bioactive molecules - and discuss various approaches for augmenting these principles to achieve organ level tissue engineering. Ultimately, the successful translation of tissue-engineered constructs into everyday clinical practice will depend upon the ability of the tissue engineer to "scale up" every aspect of the research and development process.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalOrganogenesis
Volume6
Issue number3
DOIs
StatePublished - Jul 2010
Externally publishedYes

Keywords

  • Adipose-derived stromal cells
  • Biomaterials
  • Growth factors
  • Regenerative medicine
  • Scale up
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology
  • Developmental Biology
  • Transplantation

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