Streptococci engage TLR13 on myeloid cells in a site-specific fashion

Julia Kolter, Reinhild Feuerstein, Evelyne Spoeri, Kourosh Gharun, Roland Elling, Patrick Trieu-Cuot, Tobias Goldmann, Claudia Waskow, Zhijian J. Chen, Carsten J. Kirschning, Sachin D. Deshmukh, Philipp Henneke

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Streptococci are common human colonizers with a species-specific mucocutaneous distribution. At the same time, they are among the most important and most virulent invasive bacterial pathogens. Thus, site-specific cellular innate immunity, which is predominantly executed by resident and invading myeloid cells, has to be adapted with respect to streptococcal sensing, handling, and response. In this article, we show that TLR13 is the critical mouse macrophage (MΦ) receptor in the response to group B Streptococcus, both in bone marrow-derived MΦs and in mature tissue MΦs, such as those residing in the lamina propria of the colon and the dermis, as well as in microglia. In contrast, TLR13 and its chaperone UNC-93B are dispensable for a potent cytokine response of blood monocytes to group B Streptococcus, although monocytes serve as the key progenitors of intestinal and dermal MΦs. Furthermore, a specific role for TLR13 with respect to MΦ function is supported by the response to staphylococci, where TLR13 and UNC-93B limit the cytokine response in bone marrow-derived MΦs and microglia, but not in dermal MΦs. In summary, TLR13 is a critical and site-specific receptor in the single MΦ response to β-hemolytic streptococci.

Original languageEnglish (US)
Pages (from-to)2733-2741
Number of pages9
JournalJournal of Immunology
Issue number6
StatePublished - Mar 15 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Streptococci engage TLR13 on myeloid cells in a site-specific fashion'. Together they form a unique fingerprint.

Cite this