TY - JOUR
T1 - Stroke risk and treatment in patients with atrial fibrillation and low CHA2DS2-VASC scores
T2 - Findings from the ORBIT-AF I and II registries
AU - Jackson, Larry R.
AU - Kim, Sunghee
AU - Fonarow, Gregg C.
AU - Freeman, James V.
AU - Gersh, Bernard J.
AU - Go, Alan S.
AU - Hylek, Elaine M.
AU - Kowey, Peter R.
AU - Mahaffey, Kenneth W.
AU - Singer, Daniel
AU - Thomas, Laine
AU - Blanco, Rosalia
AU - Peterson, Eric D.
AU - Piccini, Jonathan P.
N1 - Funding Information:
Dr Jackson II reports honoraria from Biotronik Inc and educational support from Medtronic, Boston Scientific, and Biotronik Inc. Kim reports no disclosures. Dr Fonarow reports research support from AHRQ and consultancy fees from Janssen and Medtronic. Dr Freeman serves as a consultant for Janssen Pharmaceuticals. Dr Gersh reports being on the data safety and monitoring board for Baxter Healthcare Corporation, Cardiovascular Research Foundation, St. Jude Medical, Boston Scientific, member of steering committee for Med-tronic, and member of executive committee for Ortho-McNeil Janssen Scientific Affairs. Dr Go receives consulting fees from Janssen Pharmaceuticals. Dr Hylek reports honoraria for consultancy from Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Janssen, Medtronic, and Pfizer. Dr Kowey reports serving as a consultant to or on the advisory board of Johnson & Johnson, Daiichi Sankyo, Sanofi, Boehringer Ingelheim, Merck, Bristol Myers Squibb, and Portola. Dr Mahaffey’s has research grants from Afferent, Amgen, Apple, Inc, AstraZeneca, Cardiva Medical, Inc, Daiichi, Ferring, Google, Johnson & Johnson, Luitpold, Medtronic, Merck, Novartis, Sanofi, St. Jude, and Tenax. Dr Mahaffey reports moderate consulting fees from Ablynx, AstraZeneca, Baim Institute, Boehringer Ingelheim, Bristol Meyers Squibb, Cardiometabolic Health Congress, Elsevier, Glaxo Smith Kline, Johnson & Johnson, Medergy, Medscape, Merck, Mitsubishi, MyoKardia, Novartis, Oculeve, Portola, Radiometer, Springer Publisher, Theravance, UCSF, WebMD. Dr Singer receives grants from Boehringer Ingelheim and Bristol-Myers Squibb. He serves as consultant to Boehringer Ingelheim, Bristol-Myers Squibb, Johnson & Johnson, Medtronic, Merck, and Pfizer. Thomas and Blanco report no pertinent relationships related to the analysis presented. Dr Peterson reports receiving research grants from the American Heart Association, the American College of Cardiology, Janssen Pharmaceutical Products, Eli Lilly & Co, and the Society of Thoracic Surgeons, as well as serving as a consultant to or on the advisory board of Merck & Co, Boehringer Ingelheim, Genentech, Sanofi-Aventis, and Janssen Pharmaceutical Products. Dr Piccini reports receiving research grants from Johnson & Johnson/Janssen Pharmaceuticals and Boston Scientific Corp, as well as other research support from Johnson & Johnson/Janssen Pharmaceuticals and consultant/advisory board fees from Forest Laboratories, Inc, Medtronic Inc, and Johnson & Johnson/Janssen Pharmaceuticals.
Publisher Copyright:
© 2018 The Authors.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Background—Current American College of Cardiology/American Heart Association guidelines suggest that for patients with atrial fibrillation who are at low risk for stroke (CHA2DS2VASc=1) (or women with CHA2DS2VASc=2) a variety of treatment strategies may be considered. However, in clinical practice, patterns of treatment in these “low-risk” patients are not well described. The objective of this analysis is to define thromboembolic event rates and to describe treatment patterns in patients with low-risk CHA2DS2VASc scores. Methods and Results—We compared characteristics, treatment strategies, and outcomes among patients with a CHA2DS2VASc=0, CHA2DS2VASc=1, females with a CHA2DS2VASc=2, and CHA2DS2VASc ≥2 in ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) I & II. Compared with CHA2DS2VASc≥2 patients (84.2%), those with a CHA2DS2VASc=0 (60.3%), 1 (69.9%), and females with a CHA2DS2VASc score=2 (72.4%) were significantly less often treated with oral anticoagulation (P<0.0001). Stroke rates were low overall and ranged from 0 per 100 patient-years in those with CHA2DS2VASc=0, 0.8 (95% confidence interval [CI] [0.5–1.2]) in those with CHA2DS2VASc=1, 0.8 (95% CI [0.4–1.6]) in females with a CHA2DS2VASc score=2, and 1.7 (95% CI [1.6–1.9]) in CHA2DS2VASc ≥2. All-cause mortality (per 100 patient-years) was highest in females with a CHA2DS2VASc score=2 (1.4) (95% CI [0.8–2.3]), compared with patients with a CHA2DS2VASc=0 (0.2) (95% CI [0.1–1.0]), and CHA2DS2VASc=1 (1.0) (95% CI [0.7–1.4]), but lower than patients with a CHA2DS2VASc ≥2 (5.7) (95% CI [5.4–6.0]). Conclusion—The majority of CHA2DS2VASc=0-1 patients are treated with oral anticoagulation. In addition, the absolute risks of death and stroke/transient ischemic attack were low among both male and females CHA2DS2VASc=0-1 as well as among females with a CHA2DS2VASc score=2.
AB - Background—Current American College of Cardiology/American Heart Association guidelines suggest that for patients with atrial fibrillation who are at low risk for stroke (CHA2DS2VASc=1) (or women with CHA2DS2VASc=2) a variety of treatment strategies may be considered. However, in clinical practice, patterns of treatment in these “low-risk” patients are not well described. The objective of this analysis is to define thromboembolic event rates and to describe treatment patterns in patients with low-risk CHA2DS2VASc scores. Methods and Results—We compared characteristics, treatment strategies, and outcomes among patients with a CHA2DS2VASc=0, CHA2DS2VASc=1, females with a CHA2DS2VASc=2, and CHA2DS2VASc ≥2 in ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) I & II. Compared with CHA2DS2VASc≥2 patients (84.2%), those with a CHA2DS2VASc=0 (60.3%), 1 (69.9%), and females with a CHA2DS2VASc score=2 (72.4%) were significantly less often treated with oral anticoagulation (P<0.0001). Stroke rates were low overall and ranged from 0 per 100 patient-years in those with CHA2DS2VASc=0, 0.8 (95% confidence interval [CI] [0.5–1.2]) in those with CHA2DS2VASc=1, 0.8 (95% CI [0.4–1.6]) in females with a CHA2DS2VASc score=2, and 1.7 (95% CI [1.6–1.9]) in CHA2DS2VASc ≥2. All-cause mortality (per 100 patient-years) was highest in females with a CHA2DS2VASc score=2 (1.4) (95% CI [0.8–2.3]), compared with patients with a CHA2DS2VASc=0 (0.2) (95% CI [0.1–1.0]), and CHA2DS2VASc=1 (1.0) (95% CI [0.7–1.4]), but lower than patients with a CHA2DS2VASc ≥2 (5.7) (95% CI [5.4–6.0]). Conclusion—The majority of CHA2DS2VASc=0-1 patients are treated with oral anticoagulation. In addition, the absolute risks of death and stroke/transient ischemic attack were low among both male and females CHA2DS2VASc=0-1 as well as among females with a CHA2DS2VASc score=2.
KW - Oral anticoagulation
KW - Outcomes registry for better informed treatment of atrial fibrillation (ORBIT-AF)
KW - Stroke
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U2 - 10.1161/JAHA.118.008764
DO - 10.1161/JAHA.118.008764
M3 - Article
C2 - 30369317
AN - SCOPUS:85052407670
SN - 2047-9980
VL - 7
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 16
M1 - e008764
ER -