Abstract
The function of transforming growth factor β (TGFβ) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgfβr2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.
Original language | English (US) |
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Article number | e975606 |
Journal | Molecular and Cellular Oncology |
Volume | 2 |
Issue number | 3 |
DOIs |
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State | Published - Jul 3 2015 |
Keywords
- TGF-β
- epithelial to mesenchymal transition
- metastasis
- pancreatic cancer
- tumor–stroma interactions
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research