Structural genomics: keeping up with expanding knowledge of the protein universe

Marek Grabowski, Andrzej Joachimiak, Zbyszek Otwinowski, Wladek Minor

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Structural characterization of the protein universe is the main mission of Structural Genomics (SG) programs. However, progress in gene sequencing technology, set in motion in the 1990s, has resulted in rapid expansion of protein sequence space - a twelvefold increase in the past seven years. For the SG field, this creates new challenges and necessitates a re-assessment of its strategies. Nevertheless, despite the growth of sequence space, at present nearly half of the content of the Swiss-Prot database and over 40% of Pfam protein families can be structurally modeled based on structures determined so far, with SG projects making an increasingly significant contribution. The SG contribution of new Pfam structures nearly doubled from 27.2% in 2003 to 51.6% in 2006.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume17
Issue number3
DOIs
StatePublished - Jun 2007

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Genomics
Proteins
Databases
Technology
Growth
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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Structural genomics : keeping up with expanding knowledge of the protein universe. / Grabowski, Marek; Joachimiak, Andrzej; Otwinowski, Zbyszek; Minor, Wladek.

In: Current Opinion in Structural Biology, Vol. 17, No. 3, 06.2007, p. 347-353.

Research output: Contribution to journalArticle

Grabowski, Marek ; Joachimiak, Andrzej ; Otwinowski, Zbyszek ; Minor, Wladek. / Structural genomics : keeping up with expanding knowledge of the protein universe. In: Current Opinion in Structural Biology. 2007 ; Vol. 17, No. 3. pp. 347-353.
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