Structural studies on the murine Ia alloantigens. IV. NH 2-terminal sequence analysis of allelic products of the I-A and I-E/C subregions

R. G. Cook, M. H. Siegelman, J. D. Capra, J. W. Uhr, E. S. Vitetta

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Murine Ia alloantigens encoded by the I-A and I-E/C subregions were isolated from radiolabeled splenic lysates and examined by NH 2-terminal sequence analysis. Haplotype-associated sequence variation was detected in the β, but not α, subunits of both the A and E/C alloantigens. The A β-polypeptides from k and b haplotypes show four differences in the 12 positions compared, whereas the E/C β-polypeptides from k and r haplotypes show two differences in the 13 positions compared. No sequence variation was detected between the A(k) and A(b) α-chains (six positions compared) or between the E/C(k) and E/C(r) α-chains (11 positions compared). Homology relationships between these murine Ia alloantigens and the human Ia (DR) alloantigens are also presented.

Original languageEnglish (US)
Pages (from-to)2232-2237
Number of pages6
JournalJournal of Immunology
Issue number6
StatePublished - Dec 1 1979


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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