Murine Ia alloantigens encoded by the I-A and I-E/C subregions were isolated from radiolabeled splenic lysates and examined by NH 2-terminal sequence analysis. Haplotype-associated sequence variation was detected in the β, but not α, subunits of both the A and E/C alloantigens. The A β-polypeptides from k and b haplotypes show four differences in the 12 positions compared, whereas the E/C β-polypeptides from k and r haplotypes show two differences in the 13 positions compared. No sequence variation was detected between the A(k) and A(b) α-chains (six positions compared) or between the E/C(k) and E/C(r) α-chains (11 positions compared). Homology relationships between these murine Ia alloantigens and the human Ia (DR) alloantigens are also presented.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Immunology|
|State||Published - Dec 1 1979|
ASJC Scopus subject areas
- Immunology and Allergy