Structural studies on the murine Ia alloantigens. VII. Further evidence for two-gene control of the E/C alloantigens

R. G. Cook, E. S. Vitetta, J. W. Uhr, J. D. Capra

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

By utilizing comparative tryptic peptide analysis of the E/C alloantigens from additional H-2 recombinant strains, the gene encoding the E/C β subunit was localized to the I-A or B subregions. By peptide mapping techniques, the E/C α- and β-chains showed little structural homology with the A alloantigen α and β subunits. In addition, comparisons of the E/C β subunits from F1 strains (b x d) with those from both parental strains revealed that in a heterozygote the β subunit from either allele (b or d) can associate with the α-chain from one allele (d). Thus, the formation of hybrid E/C antigens by cis-trans gene complementation increases the E/C alloantigen repertoire in heterozygotes.

Original languageEnglish (US)
Pages (from-to)1594-1598
Number of pages5
JournalJournal of Immunology
Volume124
Issue number4
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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