Structure of the β-from poly d(A) poly d(u)

R. Chandrasekaran, A. Radha, H. S. Park, S. Arnott

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The crystalline β-From the sodium salt of poly d(A) poly d(U) trapped in oriented fibers forms a Watson-Crick base-paired, 101 double-helix of pitch 3.2 nm. Two molecules are present in a monoclinic unit cell apparently isomorphous with β-poly d(A) polyd(T). The two chains in each molecule both carry C2’-endo puckered furanose rings but are conformationally not identical. The orientations of the A: U base-pairs relative to the helix-axis are distinctly different from those in classical B-DNA and the overall morphology of the duplex in which they reside resembles that of the a-forms of poly (purine)· poly (pyrimidine) DNA duplexes previously reported.

Original languageEnglish (US)
Pages (from-to)1203-1215
Number of pages13
JournalJournal of Biomolecular Structure and Dynamics
Volume6
Issue number6
DOIs
StatePublished - Jun 1989

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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