Study on the Endothelin Gene and its Expression

T. Masaki, Masashi Yanagisawa, A. Inoue, S. Kimura, K. Goto

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Endothelin (ET) is a potent vasoconstrictor peptide produced by vascular endothelial cells. Three distinct human endothelin genes were cloned and analysed. The results demonstrated that there were three distinct mRNAs for ET and that TPA-responsive element, mRNA stabilizing sequence, motifs for binding site of nuclear factor 1 and acute phase reactant regulatory elements were recognized in preproform ET-1 gene.

Original languageEnglish (US)
Pages (from-to)1221-1225
Number of pages5
Issue number9
StatePublished - 1990

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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