Subtropical infection leading to invasive noncutaneous squamous cell carcinoma in a 13-year-Old child

Justin R. Shinn; Shaunak N. Amin; Brian Cervenka; Christopher Wootten; Kyle Mannion; R. Theodore Cobb; James Netterville

doi:10.1016/j.xocr.2019.100111

Subtropical infection leading to invasive noncutaneous squamous cell carcinoma in a 13-year-Old child

Justin R. Shinn, Shaunak N. Amin, Brian Cervenka, Christopher Wootten, Kyle Mannion, R. Theodore Cobb, James Netterville

Research output: Contribution to journal › Article › peer-review

Abstract

Head and neck squamous cell carcinoma (HNSCC) is an extremely rare disease in children and adolescents. Although risk factors for adult HNSCC are well characterized, relatively little is known about disease etiology in pediatric patients. We describe a 13-year-old patient from a remote area of Belize with a five-year history of a progressive exophytic facial mass with cutaneous ulceration, drainage, and necrosis following a dental procedure. Final pathology revealed multifocal invasive HNSCC involving the left periorbita, maxillary sinus, and hard palate. This is the first report of early-onset HNSCC which resulted from a longstanding inflammatory process. Although uncommon, malignancy is an important sequela to consider in the management of nonhealing wounds regardless of patient age.

Original language	English (US)
Article number	100111
Journal	Otolaryngology Case Reports
Volume	11
DOIs	https://doi.org/10.1016/j.xocr.2019.100111
State	Published - Jun 2019
Externally published	Yes

Keywords

Adolescent
Chronic infection
Chronic inflammation
Neoplastic mutation
Squamous cell carcinoma

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.xocr.2019.100111

Cite this

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title = "Subtropical infection leading to invasive noncutaneous squamous cell carcinoma in a 13-year-Old child",

abstract = "Head and neck squamous cell carcinoma (HNSCC) is an extremely rare disease in children and adolescents. Although risk factors for adult HNSCC are well characterized, relatively little is known about disease etiology in pediatric patients. We describe a 13-year-old patient from a remote area of Belize with a five-year history of a progressive exophytic facial mass with cutaneous ulceration, drainage, and necrosis following a dental procedure. Final pathology revealed multifocal invasive HNSCC involving the left periorbita, maxillary sinus, and hard palate. This is the first report of early-onset HNSCC which resulted from a longstanding inflammatory process. Although uncommon, malignancy is an important sequela to consider in the management of nonhealing wounds regardless of patient age.",

keywords = "Adolescent, Chronic infection, Chronic inflammation, Neoplastic mutation, Squamous cell carcinoma",

author = "Shinn, {Justin R.} and Amin, {Shaunak N.} and Brian Cervenka and Christopher Wootten and Kyle Mannion and Cobb, {R. Theodore} and James Netterville",

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language = "English (US)",

volume = "11",

journal = "Otolaryngology Case Reports",

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T1 - Subtropical infection leading to invasive noncutaneous squamous cell carcinoma in a 13-year-Old child

AU - Shinn, Justin R.

AU - Amin, Shaunak N.

AU - Cervenka, Brian

AU - Wootten, Christopher

AU - Mannion, Kyle

AU - Cobb, R. Theodore

AU - Netterville, James

PY - 2019/6

Y1 - 2019/6

N2 - Head and neck squamous cell carcinoma (HNSCC) is an extremely rare disease in children and adolescents. Although risk factors for adult HNSCC are well characterized, relatively little is known about disease etiology in pediatric patients. We describe a 13-year-old patient from a remote area of Belize with a five-year history of a progressive exophytic facial mass with cutaneous ulceration, drainage, and necrosis following a dental procedure. Final pathology revealed multifocal invasive HNSCC involving the left periorbita, maxillary sinus, and hard palate. This is the first report of early-onset HNSCC which resulted from a longstanding inflammatory process. Although uncommon, malignancy is an important sequela to consider in the management of nonhealing wounds regardless of patient age.

AB - Head and neck squamous cell carcinoma (HNSCC) is an extremely rare disease in children and adolescents. Although risk factors for adult HNSCC are well characterized, relatively little is known about disease etiology in pediatric patients. We describe a 13-year-old patient from a remote area of Belize with a five-year history of a progressive exophytic facial mass with cutaneous ulceration, drainage, and necrosis following a dental procedure. Final pathology revealed multifocal invasive HNSCC involving the left periorbita, maxillary sinus, and hard palate. This is the first report of early-onset HNSCC which resulted from a longstanding inflammatory process. Although uncommon, malignancy is an important sequela to consider in the management of nonhealing wounds regardless of patient age.

KW - Adolescent

KW - Chronic infection

KW - Chronic inflammation

KW - Neoplastic mutation

KW - Squamous cell carcinoma

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Subtropical infection leading to invasive noncutaneous squamous cell carcinoma in a 13-year-Old child

Abstract

Keywords

ASJC Scopus subject areas

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