Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma

Yasmeen M. Attia, Heba Ewida, Mahmoud Salama Ahmed

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter offers comprehensive overview for successful stories for drug repurposing/repositioning for affiliated molecular targets related to the progression of hepatocellular carcinoma (HCC). There are detailed sections about the etiology, pathogenesis, current therapeutic regimen, and affiliated molecular targets contributing to HCC. Drug repositioning has been an emerging successful tool for the drug discovery process within the last decade to repurpose new clinical indications for already existing drugs with established safety and pharmacokinetics profiles. In this chapter, we focused on correlating the adopted strategies for drug repositioning targeting molecular targets affiliated with HCC along with different drugs preidentified for other clinical indication.

Original languageEnglish (US)
Title of host publicationDrug Repurposing in Cancer Therapy
Subtitle of host publicationApproaches and Applications
PublisherElsevier
Pages213-229
Number of pages17
ISBN (Electronic)9780128196687
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • Blinded serendipity-based repositioning
  • Computational screening-based repositioning
  • Disease network-based repositioning
  • Drug repositioning
  • Drug repurposing
  • Hepatocellular carcinoma
  • High-throughput screening-based repositioning
  • Systems biology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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