Successful treatment of persistent Burkholderia cepacia complex bacteremia with ceftazidime-avibactam

Pranita D. Tamma, Yunfan Fan, Yehudit Bergman, Anna C. Sick-Samuels, Alice J. Hsu, Winston Timp, Patricia J. Simner, Bonnie C. Prokesch, David E. Greenberg

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.

Original languageEnglish (US)
Article numbere02213-17
JournalAntimicrobial agents and chemotherapy
Volume62
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • Bacteremia
  • Burkholderia cepacia complex
  • Ceftazidime-avibactam
  • Whole-genome sequencing

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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