Successful treatment of persistent Burkholderia cepacia complex bacteremia with ceftazidime-avibactam

Pranita D. Tamma; Yunfan Fan; Yehudit Bergman; Anna C. Sick-Samuels; Alice J. Hsu; Winston Timp; Patricia J. Simner; Bonnie C. Prokesch; David E. Greenberg

doi:10.1128/AAC.02213-17

Successful treatment of persistent Burkholderia cepacia complex bacteremia with ceftazidime-avibactam

Pranita D. Tamma, Yunfan Fan, Yehudit Bergman, Anna C. Sick-Samuels, Alice J. Hsu, Winston Timp, Patricia J. Simner, Bonnie C. Prokesch, David E. Greenberg

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.

Original language	English (US)
Article number	e02213-17
Journal	Antimicrobial agents and chemotherapy
Volume	62
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02213-17
State	Published - Apr 2018

Keywords

Bacteremia
Burkholderia cepacia complex
Ceftazidime-avibactam
Whole-genome sequencing

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.02213-17

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Successful treatment of persistent Burkholderia cepacia complex bacteremia with ceftazidime-avibactam. / Tamma, Pranita D.; Fan, Yunfan; Bergman, Yehudit; Sick-Samuels, Anna C.; Hsu, Alice J.; Timp, Winston; Simner, Patricia J.; Prokesch, Bonnie C.; Greenberg, David E.

In: Antimicrobial agents and chemotherapy, Vol. 62, No. 4, e02213-17, 04.2018.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.",

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note = "Funding Information: The case study was supported by funding from the National Institutes of Health (grant K23-AI127935 awarded to P.D.T. and grant R21-AI130608 awarded to P.J.S.). None of the case authors report any conflicts of interest. Publisher Copyright: {\textcopyright} Copyright 2018 American Society for Microbiology. All Rights Reserved.",

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AU - Simner, Patricia J.

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AU - Greenberg, David E.

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AB - We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.

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Successful treatment of persistent Burkholderia cepacia complex bacteremia with ceftazidime-avibactam

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