Abstract
We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.
| Original language | English (US) |
|---|---|
| Article number | e02213-17 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 62 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2018 |
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Keywords
- Bacteremia
- Burkholderia cepacia complex
- Ceftazidime-avibactam
- Whole-genome sequencing
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Cite this
Successful treatment of persistent Burkholderia cepacia complex bacteremia with ceftazidime-avibactam. / Tamma, Pranita D.; Fan, Yunfan; Bergman, Yehudit; Sick-Samuels, Anna C.; Hsu, Alice J.; Timp, Winston; Simner, Patricia J.; Prokesch, Bonnie C.; Greenberg, David E.
In: Antimicrobial Agents and Chemotherapy, Vol. 62, No. 4, e02213-17, 01.04.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful treatment of persistent Burkholderia cepacia complex bacteremia with ceftazidime-avibactam
AU - Tamma, Pranita D.
AU - Fan, Yunfan
AU - Bergman, Yehudit
AU - Sick-Samuels, Anna C.
AU - Hsu, Alice J.
AU - Timp, Winston
AU - Simner, Patricia J.
AU - Prokesch, Bonnie C.
AU - Greenberg, David E.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.
AB - We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.
KW - Bacteremia
KW - Burkholderia cepacia complex
KW - Ceftazidime-avibactam
KW - Whole-genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85044508564&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044508564&partnerID=8YFLogxK
U2 - 10.1128/AAC.02213-17
DO - 10.1128/AAC.02213-17
M3 - Article
C2 - 29588357
AN - SCOPUS:85044508564
VL - 62
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 4
M1 - e02213-17
ER -